Correlation Analysis Between D-dimer And Postoperative Prognosis Of Patients With Liver Metastasis From Colorectal Cancer

Background:Colorectal cancer is one of the most common malignant tumors.In China,the incidence of colorectal cancer ranks 4th and 3rd among men and women respectively,and its incidence is on the rise in China and the world.Liver is the most important target organ for the hematogenous metastasis of colorectal cancer,15% to 25% of patients with colorectal cancer will have liver metastasis at the time of diagnosis,while the other 15% to 25% will have liver metastasis after radical resection of the primary focus of colorectal cancer.Liver metastasis resection is the most effective treatment method,and the median survival time of untreated liver metastasis patients is only 6.9 months.Patients with unresectable tumors have a 5-year survival rate of less than 5%.And the postoperative recurrence is still common.Therefore,it is very necessary to look for prognostic markers in patients with liver metastasis from colorectal cancer after surgery.D-dimer is a fibrin fission product,and its level is associated with tumor prognosis,recurrence and prognosis of other cancers such as non-small cell lung cancer,hepatocellular carcinoma,breast cancer,and gastric cancer.It has been shown to be associated with the progression,prognosis and recurrence of colorectal cancer.However,there are few studies on the recurrence of d-dimer after liver metastasis of colorectal cancer.Therefore,we evaluated the value of d-dimer in predicting the prognosis of CRLM.Objective:To predict the prognosis of CRLM,and the relationship between the level of d-dimer and CRLM recurrence,clinicopathological factors,inflammatory factors and patient survival rate was evaluated.Methods:We retrospectively evaluated 83 patients received liver resection in the first hospital affiliated of Fujian medical university between 2008 and 2018 to determine the correlation between D-dimer and patient survival.The cut-of value for D-dimer levels was determined using receiver operating characteristic curve analysis.Results:Significant differences occurred in the recurrence group with higher D-dimer levels(P<0.05),while the optimal cut-of value was 1.485 μg/ml.High D-dimer levels(≥ 1.485 μg/mL)were associated with poor recurrence-free survival(RFS;(P<0.05)and cancer-specific survival(CSS;P<0.05).In the multivariate analysis,D-dimer correlated with CRLM prognosis and independently predicted RFS((P<0.05)and CSS((P<0.05)Conclusion:High D-dimer levels were associated with poor RFS and CSS.D-dimer was an independent prognostic factor of RFS.Therefore,D-dimer may help predict recurrence and prognosis in patients with CRLM...