| Objective:D-dimer,one of the canonical markers of hypercoagulability,was reported to be a potential prognostic marker of colorectal cancer.However,an inconsistent conclusion existed in several published studies.Thus,we performed this meta-analysis to provide a comprehensive insight into the prognostic role for pretreatment D-dimer in colorectal cancer.Methods:Six databases(English:Pubmed,Embase and Web of Science;Chinese:CNKI,Wangfang and VIP)were utilized for the literature retrieval.Retrieve the time to June 12,2017;Newcastle-Ottawa Scale(NOS)was employed to estimate the quality of each eligible studies.Hazard ratio(HR)was pooled by Stata 12.0.In this study,HR was used to evaluate the prognostic effect of plasma d-dimer in colorectal cancer patients.Results:A total of fifteen studies(2283 cases)corresponded to this meta-analysis and provided available data to evaluate the prognostic role of D-dimer for colorectal cancer.The pooled HR reached 2.167(95%.CI(confidence interval):1.672-2.809,P<0.001)utilizing random effect model due to obvious heterogeneity among the included studies(I~2:73.3%;P<0.001).To explore the heterogeneity among the studies,we conducted a sensitivity analysis and found a heterogeneous study.After removing it,the heterogeneity reduced substantially(I~2:0%;P=0.549)and we obtained a more convincing result by fixed effect model(HR=2.143,95%CI=1.922-2.390,P<0.001,14 studies with2179 cases).Conclusion:In summary,high pre-treatment plasma D-dimer predicts poor survival of colorectal cancer based on the current evidence.It may be a predictive factor for prognosis of colorectal cancer. |
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