Study On Atrial Fibrillation And SCN5A Gene Polymorphism In Tibetan And Han Nationalities At High Altitude

Objective: This study aimed to explore the relationship between H558 R polymorphism of the SCN5 A gene and AF in Tibetan and Han nationalities at high altitude.Methods: A total of 50 Tibetan and 50 Han patients with AF at the same altitude(2260 m)were included.Meanwhile,the general clinical data of patients without AF(50 Tibetan and 50 Han)matched with the data of patients with AF were included during the same period.The blood samples of patients were collected to extract DNA.The general information,laboratory examination,color Doppler echocardiography,and genotypes and alleles of each group were analyzed.The multivariate logistic regression analysis was used to determine the independent risk factors for AF.Results: The genotype and allele frequency in the AF group were significantly different from those in the non-AF group,regardless of Tibetan or Han nationalities.No significant difference was found in the genotype or allele frequency between the Tibetan and Han patients with AF.The logistic regression analysis of the total population revealed that coronary heart disease,age,total cholesterol(TC),left atrial diameter,and G allele were independent risk factors for AF occurrence.Conclusion: The occurrence of AF in Tibetan and Han nationalities at high altitude is associated with the polymorphism of H558 R locus of the SCN5 A gene.The G allele is an independent risk factor for the occurrence of AF in Tibetan and Han nationalities.