Association Between The SCN5A Gene H558R Polymorphism And Atrial Fibrillation In The Uygur And Han Populations Of Xinjiang

Objective:Atrial fibrillation(AF)is one the most common and complex types of clinical arrhythmia syndromes.In recent years,an association between SCN5 A gene polymorphisms and atrial fibrillation has received a significant amount of attention.The present study aimed to investigate the correlation between the H558 R polymorphism in SCN5 A and atrial fibrillation(AF)occurrence in Uygur and Han populations of Xinjiang,China.Method: We selected 100 Uygur and 100 Han patient cases in the Xinjiang region who had non-valvular atrial fibrillation as well as 100 Uygur and 100 Han cases of non-AF patients as a control group.DNA was prepared from peripheral blood samples,and PCR and DNA sequencing were applied to determine genotype and allele frequencies of SCN5 A gene H558 R polymorphism.Results:In both Uygur and Han populations,genotype and allele frequencies were significantly different between cases and controls group(both P<0.05).Moreover,genotype and allele frequencies differed significantly between Uygur AF patients and Han AF patients(P<0.05).Logistic regression analysis showed that the G allele was correlated with the occurrence of AF(OR =2.189,95%CI=1.360-3.523,P=0.001)?Conclusion:These findings suggest the existence of a correlation between the H558 R polymorphism of SCN5 A gene and AF occurrence in the Uygur and Han populations of Xinjiang,and indicate that the G allele might be an independent risk factor for predisposition to AF.The genotype and allele frequency was significantly different between Uygur and Han AF patients This could be explained by differences in genetics,locations,and lifestyles of the two populations.