The Therapeutic Effect Of Huazhuo Jiedu Shugan Prescription On Senile Depression With Insomnia

Objective: Based on the theory of turbid poison in traditional Chinese medicine,to observe the clinical effect of Huazhuo Jiedu Shugan Recipe on senile depression with insomnia.Methods: From November 2018 to January 2020,60 elderly patients with depression of qi stagnation type and insomnia were selected.Patients were randomly divided into treatment group,and control group.The treatment group was treated with Huazhuo Jiedu Shugan recipe.The control group was treated with mirtazapine orally.The treatment course was continued 8 weeks,and the time nodes of pre-treatment,2weeks,4 weeks and 8 weeks were selected for integral evaluation.Hamilton Depression Rating Scale(HAMD-24),Pittsburgh sleep quality index scale(PSQI)and the improved TCM syndrome score scale were used to compare the therapeutic effects of the treatment group and the control group before,during and after treatment.SPSS19 was used to test and analyze the two groups of data.Results:(1)According to the Hamilton Depression Scale(HAMD-24),there was no significant difference between the therapeutic group and control group after 2 weeks of treatment(P>0.05).After 4 weeks and 8 weeks,the score of the treatment group was significantly higher than that of the control group(P<0.01).The scores of anxiety/somatization,cognitive impairment,retardation and sense of despair in Hamilton Depression Scale were compared.The scores of anxiety/ somatization,cognitive impairment and retardation in the two groups were all decreased,and the two groups of drugs were effective,but the scores of the treatment group were more decreased.The comparison of scores in the eighth week showed that the treatment group improved anxiety and somatization,P<0.01 Compared with the control group,the effect of symptom group was more obvious.After 4 and 8 weeks of treatment,the scores of the two groups were reduced,indicating that both groups had therapeutic effect,but there was no significant difference between the therapeutic group and control group(P>0.05),indicating that the therapeutic group and thecontrol group had the same effect in improving the symptoms of despair.(2)Pittsburgh sleep quality index(PSQI)scale score comparison: After four weeks of treatment,there was no significant difference between the therapeutic group and the control group(P> 0.05),indicating that the two groups had the same effect in four weeks of treatment;after eight weeks of the cure,the difference of the two groups was statistically significant(P<0.05),explaining that the improvement of insomnia symptoms in the therapeutic group was better than that in the control group.The scores of sleep quality,sleep time,sleep time and sleep disorder in Pittsburgh sleep quality index were compared.The score of sleep quality in the control group was significantly better than that in the treatment group at the fourth week(P<0.01),but with the increase of cure time,there was no significant difference between the therapeutic group and the control group in improving sleep quality after the eighth week(P>0.05),indicating that the control group was faster than the treatment group in improving the onset time of insomnia.Sleep time score comparison,the control group was significantly better.(3)According to the improved TCM syndrome score comparison: after 4 weeks and 8weeks of treatment,the scores of the therapeutic group and the control group are very significantly different(P<0.01).According to the score reduction comparison,the therapeutic group is significantly better than the control group in improving TCM symptoms.Before treatment,there was no significant difference between the therapeutic group and the control group(P>0.05).After 4 and 8 weeks of treatment,the scores of the two groups decreased,but the scores of the traditional Chinese medicine group decreased more,the divergence between the two groups was very significant(P<0.01).Treatment effect: Comparison of clinical efficacy of depression: after 8 weeks of treatment,the total effective rate of the therapeutic group was 96.6% and that of the control group was 93.1%.The total effective rate of the treatment group was better than that of the control group(P<0.05).The total effective rate of sleep improvement in the treatment group and the control group after 8 weeks of treatment was 93.1%.There was no significant difference in the total effective rate of sleep improvement between the two groups(P>0.05).In the treatment group,most of the patients with depression and insomnia were "clinically controlled" and "Markedly effective";in the control group,most of the patients were "Markedly effective" and "effective".To sum up,Huazhuo Jiedu Shugan formula has a definite effect on the treatment of senile depression with insomnia.Conclusion:(1)Huazhuo Jiedu Shugan prescription can obviously improve the clinical symptoms of the elderly patients with depression of qi stagnation and fire type and insomnia.The effect of mirtazapine is better than that of mirtazapine in the treatment of depression.(2)Huazhuo Jiedu Shugan prescription can obviously reduce the scores of hamd-24 and PSQI in the elderly patients with depression of qi depression and fire type and insomnia.(3)The therapeutic effect of Huazhuo Jiedu Shugan prescription on senile depression with insomnia is definite,which is worth more large-scale clinical research and application.