Analysis The Relationship Of Periodontitis With Serum Homocysteine And Coronary Heart Disease

Objective:Compared the serum homocysteine(HCY)levels and clinical periodontal indexes in coronary heart disease patients with periodontitis and coronary heart disease patients and periodontitis and healthy swarm,to explore the correlation between periodontitis and serum HCY,to provide clinical basis for the correlation between periodontitis and coronary heart disease,and to provide new ideas for the prevention and treatment of periodontitis and coronary heart disease in the future.Methods:A total of 103 cases with coronary heart disease were selected from the Department of Cardiology of Shanxi People's Hospital,according the results of periodontal examination,61 cases were divided into the coronary heart disease with periodontitis(group C+P)and 42 cases of coronary heart disease alone(group C).In addition,in the same period,a total of 100 cases were selected from the group of people who underwent physical examination and were excluded from systematic diseases at the Physical Examination Center of Shanxi Provincial People's Hospital,including 54 healthy swarm(Group H),46 cases of periodontitis alone(group P).All cases underwent standard oral examinations and were collected early morning fasting venous blood to detect serum homocysteine(HCY),blood glucose and blood lipid levels.Statistical analysis was performed using SPSS22.0 statistical software to compared periodontal indicators,serum HCY,blood lipid,and blood glucose levels between the four groups.Results:1.Comparison of general clinical data among 4 groupsThere was no significant difference in age,sex and body mass index between the four groups(P>0.05);Systolic blood pressure: C+P group and C group were higher than P group or H group(P<0.05);Diastolic blood pressure: C+P group and C group were both higher than H group(P<0.05).2.Comparison of periodontal conditions among among 4 groupsComparison of the average level of PD: Group P and group C were higher than group H,with difference significantly among the four groups(P<0.05).Group C+P was higher than group P,but with no differences significantly;Comparison of the average level of SBI: Pairwise comparison of the two groups showed significantly differences,and C+P group > group P >C group >H group(P<0.05);Comparison of the average level of CAL: Group P was higher than group H,with differences significantly(P<0.05).Group C was higher than group H,group C+P was higher than group P,but with no differences significantly.3.Comparison of biochemical level among 4 groupsThere was no significant difference in the results of TC,TG and FG among the four groups(P>0.05);The average level of HDL-C: groups C and groups C+P were lower than in group H and group P,with differences significantly(P<0.05);The average level of LDL-C: group C+P,group C was higher than H group,group C was higher than group P,with differences significantly(P<0.05).4.Comparison of serum HCY levels among 4 groups and correlation analysis with periodontal indicatorsThe average level of serum HCY: group C+P was higher than group C and group P,with differences significantly(P<0.05);group C and group P was both higher than group H with differences significantly(P<0.05).Serum HCY level was positively correlatedwith CAL,PD and SBI(P<0.05).Conclusion:1.Under the condition of similar general clinical data of all research objects,the periodontal status of coronary heart disease patients were worse than healthy swarm and the coronary heart disease patients with periodontitis were worse than simple periodontitis patients.2.Periodontal inflammation can increase the serum HCY level,and the greater the inflammation,the higher the HCY level.