Correlation Analysis About Clinical Features And Prognosis Between Different Classification Methods Of Peripheral Blood Eosinophils In AECOPD

Objective: To observe the percentages and absolute values of eosinophils in peripheral blood of patients of acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and explore the relationship between different classification methods of peripheral blood eosinophils with clinical features and prognosis of AECOPD?Methods: Collect clinical data of 134 AECOPD patients,who admitted to the Department of Respiratory and Critical Care Medicine of the First Hospital of Shanxi Medical University from December 2018 to December 2019,such as hospitalization time,mechanical ventilation frequency and other clinical data,blood cell analysis(PLT?EOS and EOS%?NEUT and NEUT%?PY and PY%),procalcitonin(PCT),coagulation index(FDP?D-D?FIB),albumin(ALB),Lung function(FEV1/FVC?FEV1%pred),neutrophil lymphocyte rate(NLR),fibrinogen serum albumin rate(FAR),platelet lymphocyte rate(PLR)and other auxiliary examination results.According to two different values of EOS in peripheral blood,namely,the percentage of EOS is 2% and the absolute count is 100/?l,all patients are divided into non-EOS increased and EOS increased types.Comparing the difference of clinical characteristics,inflammation indicators and prognostic factors of patients under those two different node value classification methods.Results: 1.group A vs group B,group 1 vs group 2,the distribution of patients,gender,age,family history,the comorbidities of electrolyte disorders,emphysema,cardiovascular,endocrine,and positive sputum culture rates were not statistically significant(P>0.05);the hospitalization time and mechanical ventilation rate were used to reflect the Prognosis of patients.Within the same node value group,hospitalization times of patients in group A(EOS% <2%)and group 1(EOS<100/?l)were Longer,and the mechanical ventilation rates were higher(P> 0.05),which prompted those patients had worse prognosis.2.Comparing within the same node value group,FEV1/FVC,FEV1% pred had no statistical significance(P> 0.05),but the FDP,D-D,FIB,PCT,NLR,FAR,PLR and pulmonary hypertension combined rates were higher in patients with EOS% <2% and EOS <100/?l than EOS%?2% and EOS?100/?l,and the differences were statistically significant(all P <0.05).3.Comparison between groups of different node value.Compared with group A vs group 1,group B vs group 2,there were no significant differences in clinical characteristics,laboratory indicators,and prognosis(P> 0.05).4.Patients who completed the analysis of blood cells in and out of the hospital of the group had a higher eosinophil counts and percentages at discharge than those at admission(P <0.05),and there was a positive correlation with EOS and EOS% between discharge and admission respectively.Conclusion: 1.Eosinophils can be used as an important indicator to evaluate the severity and prognosis of AECOPD.Non-eosinophilic increased patients have a poor prognosis.2.Different node value classifications(EOS% is 2% and EOS is 100/?l)all can reflect the clinical characteristics and prognosis of patients to a certain degree.Patients with AECOPD of EOS%?2% and EOS?100 /?l have a short hospital stay,low mechanical ventilation rate,low inflammatory index,mild disease,and good prognosis.3.In terms of reflecting the clinical characteristics and prognosis of patients,there is no significant difference between those two different node value classification methods(EOS% is 2% and EOS is 100/?l).