The Related Risk Factors And Clinical Analysis Of Colorectal Cancer

Objective:Analyze the risk factors and clinical data of colorectal cancer,an d provide scientific evidence for the development of preventive measures for c olorectal cancerMethods:A new colorectal cancer diagnosed by postoperative pathology and endoscopic pathology at the First Affiliated Hospital of Fujian Medical Univer sity from April 2017 to April 2018 was collected and diagnosed by internation al classification of diseases(ICD).For patients with colorectal cancer(ICD10),cases with non-cancer and non-gastrointestinal symptoms mainly treated with t he same age were selected as the control group.The clinical data of the cases were collected including general conditions including BMI,personal life histor y,and previous medical history such as hypertension,diabetes,gallbladder infla mmation,gallstones,cholecystectomy,chronic appendicitis,appendectomy,chron ic gastritis,colon polyps.Laboratory indicators include:BMI,fibrinogen,total cholesterol,high-density lipoprotein,low-density lipoprotein,very low-density li poprotein,apolipoprotein a1,apolipoprotein b,albumin and other serum indicat ors.The clinical data of the subjects were retrospectively analyzed.The contin uous variables of the samples were average±standard deviation(?x±s).The t-test was used for comparison between the two groups.The composition ratio a nd?~2 test were used to calculate the exposure factors.The odds ratio(OR val ue)for colorectal cancer was estimated to be relative risk and 95%confidence interval(95%CI),and multivariate related categorical variables were analyzed by unconditional logistic regression.Multivariate related continuous variables were analyzed by linear regression.The P value was taken in both directions,with a significant difference of P<0.05.Results:Results of univariate analysis:history of diabetes,smoking,drinking,stomach diseases,chronic cholecystitis,cholelithiasis,chronic appendicitis,hist ory of intestinal polyps,BMI,fibrinogen CEA and colorectal cancer were relat ed.Family history of hypertension gallbladder polyp appendectomy was not sig nificantly associated with colorectal cancer.Multivariate regression analysis results:diabetes(OR=5.396,P<0.01),smoking(OR=2.889,P=0.012),alcohol consumption(OR=10.757,P<0.01),chronic chole cystitis(OR=5.006,P=0.024)is an independent risk factor for colorectal cance r(P<0.05).BMI(t=5.944,P<0.01),very low-density lipoprotein(t=3.987,P<0.01),apolipoprotein a1(t=5.906,P<0.01),apolipoprotein b(t=4.029,P<0.01),tot al cholesterol(t=4.739,P<0.01),fibrinogen(t=2.361,P=0.019),and CEA(t=1.985,P=0.049)had significant effects on colorectal cancer.Conclusions:1.Diabetes mellitus,smoking,alcohol consumption and chronic cholecystitis are independent risk factors for colorectal cancer.2.Fibrinogen and CEA are highly suggestive of the possibility of colorectal ca ncer and are of value in assistant diagnosis.Very low density lipoprotein,apoli poprotein a1,apolipoprotein B and total cholesterol levels are closely related to the occurrence of colorectal cancer.Effective control of indicators may reduce the risk of colorectal cancer.