The Value Of Severe Vitamin D Deficiency In Predicting The Mortality Risk Of Patients With Liver Cirrhosis

Background:Vitamin D plays an important role in the pathological process of chronic liver disease(CLD),and the degree of vitamin D deficiency is related to the severity of CLD.The aim of our study was to investigate the association between severe vitamin D deficiency and the risk of all-cause mortality in patients with liver cirrhosis(LC).Methods:The PubMed,Embase,and Cochrane Library databases were searched systematically for eligible studies from the earliest available date to 15 January 2019.The exposure and outcome of interest was serum vitamin D levels and all-cause mortality,respectively.The pooled risk ratio(RR)values and their 95% confidence intervals(CIs)were calculated through a meta-analysis.Results:Eight studies published from March 2013 to January 2019 were included,involving 1,339 patients with LC.The meta-analysis showed that a severe serum vitamin D deficiency was associated with an increased risk of mortality in patients with LC(RR = 1.79;95% CI 1.44—2.22;p < 0.01).Conclusions:Our meta-analysis confirmed the association between severe vitamin D deficiency and mortality risk,suggested serum vitamin D level as a new index to predict the prognosis,and emphasized the importance of vitamin D supplementation in LC patients.