Risk Factors And Short-term Prognosis Of Spontaneous Fungal Peritonitis In Patients With Liver Cirrhosis

Aim: This study aimed to illustrate the risk factors,clinical features and short-term prognosis of spontaneous fungal peritonitis(SFP).It helps us to make prevention and treatment plans in clinical work.Methods: We performed a matched case-control study between Jan 1,2007 to Dec30,2018.Patients with SFP were assigned as case group.Sex,age and timing matched Patients with spontaneous bacteria peritonitis(SBP)were assigned as control group and further divided in control-1 group(positive bacteria culture)and control-2 group(negative bacteria culture).Clinical features,laboratory parameters,severity models and prognosis were compared between case group and control group.Logistic regression analysis and Cox regression model were used to recognize risk factors of occurrence and short-term mortality for SFP,respectively.Results: Patients with SFP exhibited more severe in systemic inflammatory,and higher 15-day mortality than control group.Antibiotics administration(case vs.control-1 OR=1.063,95%CI: 1.012-1.115,P=0.014;case vs.control-2 OR=1.054,95%CI: 1.014-1.095,P=0.008)remarkably increased the occurrence of SFP or fungiascites.Hepatorenal syndrome(HR: 3.865,95%CI: 1.082-13.797),total bilirubin(HR: 1.005,95%CI: 1.002-1.008),creatinine(HR: 1.010,95%CI: 1.001-1.020)represented independent predictors for SFP-related early mortality.Conclusion: Long-term antibiotics administration increase the incidence of SFP and renal dysfunction are closely related to short-term mortality.