Clinical Observation Of Zhang Shi Zhuangguxiaobi Decoction Combined With Glucosamine Hydrochloride In The Treatment Of Knee Osteoarthritis With Deficiency Of Liver And Kidney Type

Objective This topic is to observe the clinical efficacy of Zhangshi Zhuanggu Xiaobi Decoction combined with glucosamine hydrochloride in the treatment of knee osteoarthritis with deficiency of liver and kidney type,and to evaluate the efficacy of Zhang's Zhuanggu Xiaobi Decoction on KOA of liver and kidney deficiency type,and to provide relevant research data and feasible treatment reference scheme for the clinical effective prevention and treatment of KOA.Methods From January 2019 to December 2019,there were 60 inpatients and outpatients of knee osteoarthritis with deficiency of liver and kidney type who met the criteria of diagnosis,inclusion and exclusion in the department of orthopaedics of Zhangzhou Traditional Chinese Medicine Hospital which affiliated to Fujian University of Chinese Medicine.The patients were randomly divided into control group(30 cases)and treatment group(30 cases).Both groups were received conventional basic treatment,while the control group was given glucosamine hydrochloride capsules(2 capsules at a time,3 times a day)on conventional basic treatment,the treatment group was given Zhang's Zhuanggu Xiaobi addition and subtraction on the basis of the control group,and both groups were treated for 3 months.Comparing the VAS,WOMAC and TCM syndrome score of the two groups before treatment and 1,2 and 3 months after treatment,and comparing the curative effect and clinical effect of TCM symptoms between before treatment and 3 months after treatment.Perform statistical analysis and draw conclusions.After effectiveness evaluation,and statistical analysis,draw the conclusion.Results 1.There was no significant difference in the VAS score,WOMAC score and TCM symptom score between the two groups before treatment(P > 0.05),and they were comparable.VAS score: The difference of VAS scores between the two groups after 1 month,2 months,and 3 months was statistically significant(P < 0.01);after 1 month,2 months,and3 months of treatment in the two groups compared with the VAS score of pre-treatment,the differences were statistically significant(P < 0.01).WOMAC score: There was no significant difference in the WOMAC score between the two groups after 1 month of treatment(P > 0.05).The comparison difference of the WOMAC score after 2 months and 3months between the two groups was statistical significant(P < 0.01);after 1 month,2months,and 3 months of treatment in the two groups compared with the WOMAC score of pre-treatment,the differences were statistically significant(P < 0.01).TCM symptom score:The comparison difference of TCM symptom score between the two groups after 1 month,2months,and 3 months was statistically significant(P < 0.05);after 1 month,2 months,and 3months of treatment in the two groups compared with the TCM symptom score of pre-treatment,the differences were statistically significant(P < 0.01). 2.Analysis of efficacy of TCM syndromes: The control group: Clinical control in 1 cases(3.33%),marked effect in 3 cases(10.00%),effective in 18 cases(60.00%),ineffective in8 cases(26.67%),total effective rate of 73.33%;The treatment group : Clinical control in 4cases(13.33%),marked effect in 9 cases(30.00%),effective in 13 cases(43.33%),ineffective in 4 cases(13.33%),total effective rate of 86.66%;comparison of the totaleffective rate between groups,the difference it has statistical significance(P < 0.05),indicating that the treatment group is better than the control group.3.Analysis of clinical efficacy: The control group: Clinical control in 2 cases(6.77%),marked effect in 4 cases(13.33%),effective in 17 cases(56.67%),ineffective in 7 cases(23.33%),total effective rate of 76.67%;The treatment group : Clinical control in 6 cases(20.00%),marked effect in 8 cases(26.67%),effective in 13 cases(43.33%),ineffective in 3 cases(10.00%),total effective rate of 90.00%;comparison of the total effective rate between groups,the difference it has statistical significance(P < 0.05),indicating that the treatment group is better than the control group.Conclusion Zhangshi Zhuanggu Xiaobi Decoction combined with glucosamine hydrochloride in the treatment of liver and kidney deficiency type knee osteoarthritis can effectively reduce pain,improve joint stiffness and functional activities of the knee joint,etc.,thereby improving the quality of life of patients.Compared with the simple use of glucosamine hydrochloride,this treatment of liver and kidney deficiency type knee osteoarthritisis more effective.