Clinical Study Of Three Methods To Prevent Recurrence After Hysteroscopic Resection Of Endometrial Polyps

Objective:The purpose of this study was to compare the efficacy of Drospirenone and ethinylestradiol II,Dydorgesterone tablrts and levonorgestrel intrauterine system in preventing the recurrence of endometrial polyps in patients with endometrial polyps after hysteroscopic endometrial polypectomy,so as to guide the clinic to adopt the best method to prevent the recurrence of endometrial polyps after hysteroscopic endometrial polypectomy.Method:A total of 240 patients who underwent hysteroscopic endometrial polypectomy in the second department of Northwest Women's and Children's Hospital from October2017 to September 2018 were collected.After operation,60 patients with endometrial polyps only underwent hysteroscopic endometrial polypectomy were taken as the control group.Among the postoperative adjuvant treatment measures,60 patients were treated with Drospirenone and ethinylestradiol II as group A,60 patients with Dydorgesterone tablrts as group B,and 60 patients treated with levonorgestrel intrauterine system as group C.the patients were divided into three groups: group A(n = 60),group B(n = 60)and group C(n =60).The age,pregnancy,parity,endometrial thickness,menstruation and polyp types of the patients in the four groups were collected,and the endometrial thickness,menstruation,polyp recurrence and adverse drug reactions were followed up at 3,6 and 12 months after operation.Results:1.The endometrial thickness of the four groups decreased 3 months and 6 months after operation(P<0.05),and the endometrial thickness of group A,B and C decreased 12 months after operation(P<0.05).There was no significant difference in endometrial thickness between the control group and the control group 12 months after operation(P>0.05).2.There was no significant difference in endometrial thickness among the four groups3 months after operation(P>0.05).There was significant difference in endometrial thickness among the four groups 6 months after operation(P<0.05).The thickness of endometrium in group A,group B and group C was lower than that in the control group P<0.05).The thickness of endometrium in group C was lower than that in group A and group B(P<0.05).There was no significant difference in endometrial thickness between group A and group B(P>0.05).At 12 months after operation,there was significant difference in endometrial thickness among the four groups(P<0.05).The thickness of endometrium in group A,group B and group C was lower than that in the control group(P<0.05).The thickness of endometrium in group C was lower than that in group A and group B(P<0.05).There was no significant difference in endometrial thickness between group A and group B(P>0.05).3.There was no significant difference in the menstruation improvement rate among the four groups at 3 months after operation(P>0.05),but at 6 months after operation,the menstruation improvement rate in group C was higher than that in the control group(P<0.05),and there was no significant difference in the menstruation improvement rate among the control group,group A and group B(P>0.05).there was significant difference in the menstruation improvement rate among the four groups at 12 months after operation(P<0.05).The menstruation improvement rate in group A,group B and group C was higher than that in the control group(P<0.05).The menstruation improvement rate of group C was higher than that of group A and group B(P<0.05).There was no significant difference in the rate of menstruation improvement between group A and group B(P>0.05).4.There was no significant difference in recurrence rate among the four groups at 3months and 6 months after operation(P>0.05).At 12 months after operation,the recurrence rate in group A,group B and group C was lower than that in the control group(P<0.05).The recurrence rate in group C was lower than that in group A and group B(P<0.05).There was no significant difference in recurrence rate between group A and group B(P>0.05).5.The incidence of adverse reactions in group C was lower than that in group A and group B(P<0.05).There was no significant difference in the incidence of adverse reactions between group A and group B(P>0.05).Conclusion:1.Hysteroscopic endometrial polypectomy is effective in the treatment of endometrial polyps.Postoperative administration of Drospirenone and ethinylestradiol II,Dydorgesterone tablrts and levonorgestrel intrauterine system can effectively reduce the thickness of endometrium,improve menstruation and prevent recurrence of endometrial polyps.2.After hysteroscopic electroresection of endometrial polyps,the therapeutic effect of levonorgestrel intrauterine system is more obvious than that of Drospirenone and ethinylestradiol II and Dydorgesterone tablrts,and the adverse reaction is lower than that of Drospirenone and ethinylestradiol II and Dydorgesterone tablrts,and it is convenient and safe to use.It is more suitable for patients with endometrial polyps without pregnancy needs.3.The effect of Drospirenone and ethinylestradiol II after hysteroscopic electroresection of endometrial polyps is similar to that of Dydorgesterone tablrts.