Study On Correlation Between Serum Uric Acid And Fetal Outcomes In Pregnant Women With Pre-eclampsia

Objective: To investigate the relationship between serum uric acid and fetal outcomes in pre-eclampsia pregnant women before delivery,and the predictive value of serum uric acid for fetal outcomes.Methods: A retrospective case-control study was conducted on 204 pregnant women with pre-eclampsia who delivered in the First hospital of Lanzhou University from September 2017 to September 2019.Relevant clinical data at time of delivery were collected for each pregnancy.Logistic regression analysis was used to test the relationship between serum uric acid level and premature delivery,small for gestational age and Neonatal intensive care unit(NICU)transfer.Linear regression analysis was used to test the relationship between serum uric acid level and birth weight of newborn.The predictive value of serum uric acid level for premature delivery,small for gestational age and NICU transfer were measured by receiver operating characteristic curve.Results: 1.Logistic regression analysis showed that serum uric acid,gestational age-corrected uric acid z-score and gestational age-corrected hyperuricemia were the influencing factors for premature delivery,small for gestational age,and NICU transfer(P<0.05).And serum uric acid(OR 1.006;95% CI 1.002-1.009),gestational age-corrected uric acid z-score(OR 2.034;95% CI 1.555-2.660),and gestational age-corrected hyperuricemia(OR 5.175;95% CI 2.282-11.738)were independent risk factors for preterm delivery after adjusting factors such as the severity of pre-eclampsia and the mode of delivery.And serum uric acid(OR 1.008;95%CI1.004-1.011),gestational age-corrected uric acid z-score(OR 1.572;95%CI1.246-1.983),gestational age-corrected hyperuricemia(OR 2.380;95%CI1.141-4.964)were independent risk factors of small for gestational age after adjusting factors such as the severity of pre-eclampsia,the mode of delivery andgestational age.And serum uric acid(OR 1.011;95% CI 1.006-1.017),gestational age-corrected uric acid z-score(OR 1.910;95% CI 1.388-2.626),gestational age-corrected hyperuricemia(OR 3.714;95% CI 1.535-8.989)were independent risk factors of NICU transfer after adjusting factors such as the severity of pre-eclampsia,the mode of delivery and gestational age.2.Linear regression analysis showed that serum uric acid was able to affect the birth weight of newborn(?-0.739;P<0.05).3.Receiver operating characteristic curve showed that serum uric acid level has the moderate predictive value for preterm birth(AUC 0.724;P<0.05),small for gestational age(AUC 0.719;P<0.05),NICU transfer(AUC 0.808;P<0.05).Conclusion: Serum uric acid level in pre-eclampsia pregnant women before delivery is an independent risk factor of premature delivery,small for gestational age and NICU transfer.And serum uric acid level in pre-eclampsia pregnant women before delivery has the good predictive value for NICU transfer.In clinical practice,serum uric acid,gestational age-corrected uric acid z-scores,and gestational age-corrected hyperuricemia may be used to guide the management of fetal outcomes in pregnant women with pre-eclampsia.