Association Of Epicardialadipose Tissue With Essential Hypertension: A Meta-analysis

To conduct a meta-analysis on the association of epicardial adipose tissue(EAT)thickness and volume with essential hypertension.PubMed,EMBASE,and Cochrane databases were systematically reviewed for all observational studies assessing the association of EAT thickness(EAT-t)and volume(EAT-v)with essential hypertension.There were 39 observational studies and 8,983 subjects included in the meta-analysis.We calculated pooled odds ratio(OR)and 95% confidence intervals(CI)for the association of EAT with essential hypertension,and the results showed that EAT-t(OR: 1.59,95% CI: 1.09–2.33,P<0.001)and EAT-v(OR: 1.82,95% CI: 1.33–2.19,P<0.001)were associated with essential hypertension.Accordingly,the analysis indicated that hypertensive patients had a higher mean of EAT-t(SMD=0.64,95% CI: 0.44-0.83,p<0.001)and EAT-v(SMD:0.69,95% CI:0.34-0.1.05,p<0.001)than normotensive individuals.Additionally,higher mean of EAT-t(SMD=0.85,95% CI=0.49-0.1.21,p<0.001)and EAT-v(SMD=0.83,95% CI=0.31-1.34,p=0.002)were found in non-dipper hypertensive patients than those in dipper hypertensivepatients,but we didn't find significant difference in EAT-t among patients with different grades of hypertension.We also investigated the association of EAT with complications in hypertensive patients,and the results showed that EAT was increased in hypertensive patients with arteriosclerotic cardiovascular disease(ASCVD)and cardiac hypertrophy and dysfunction than those without.