The Amplification Of Epicardial Adipose-precipitating Factor For Coronary Heart Disease

Summary Coronary heart disease become a serious threat to health because of its highmorbidity. However, the occurrence and development of the mechanism is not yet clear.In recent years, studies suggest that adipose tissue is no longer the traditional sense ofthe energy repository,but also the body’s largest endocrine organ. Visceral fat, especiallythe fat around the blood vessels and heart is no longer considered as support effect、machinery protection、weakening of vascular tone and distorted、participate in vascularremodeling to heart and blood vessels, but also as a source of the blood vesselsautocrine and paracrine to cytokines, matrix, and the fat factor. In healthy state, thenormal accumulation of epicardial fat may play a protective role on vascular functionand energy separation, but the over-amplified the of fat making it a harmful lipidtoxicity, procoagulant and proinflammatory sexual organs to the heart and coronaryarteries.Bcause of conventional small experimental animals such as rats and mice，itsepicardial fat little or absence of, therefore until the recent years its pathophysiology andmetabolism in the development of coronary heart disease be more attentioned. In-depthstudy to epicardial fat and its secretion of adipocytokines will provide a new focustarget in prevention and treatment of coronary heart disease. In this paper, the prediction,diagnosis and treatment value,the endocrine and genetic level,s affect of the epicardialadipose tissue to coronary heart disease will be high light.Its value as a new therapeutictargets will be also noticed.