The Fetal Inflammatory Response Syndrome And Adverse Neonatal Outcomes:A Meta-analysis

Background:The clinical performance of fetal inflammatory response syndrome(FIRS)is often atypical.Some studies have suggested that FIRS may lead to severe complications in the neonatal period,but not all studies have reached consistent conclusions.The aim of this meta-analysis is to investigate whether adverse neonatal outcomes is associated with FIRS.Methods: PubMed,Embase,Cochrane Library,Google Scholar and CKNI were used in this study.The adverse neonatal outcomes data including neonatal early-onset sepsis(EOS),bronchopulmonary dysplasia(BPD),periventricular leukomalacia(PVL),intraventricular hemorrhage(IVH),respiratory distress syndrome(RDS)and neonatal death were collected to make analysis.Results: A total of 10 articles(1116 patients)were included in this study.Compared to the non-FIRS group,the FIRS group was associated with higher incidence of adverse neonatal outcomes,such as EOS(RR=3.10,95% CI: 1.26,7.65;P=.014),BPD(RR=5.93,95% CI=4.35,8,08;P<.001),IVH(RR= 4.89,95% CI=2.96,8.08;P<.001),PVL(RR=3.32,95% CI: 1.73,6.40;P<.001),RDS(2.35,95% CI=1.67,3.31;P<.001)and the neonatal death(RR=7.04,95% CI: 3.34,14.85;P<.001).Conclusion: The fetal inflammatory response syndrome(FIRS)isassociated with higher incidence of adverse neonatal outcomes,and is a risk factor of severe neonatal morbidity or mortality.