Correlation Analysis Of Maternal Thyroid Function And Placental Function

Purpose:The placenta which determines a healthy pregnancy and is associated with some pregnancy complications,is an important temporary organ of mammals during pregnancy.Thyroid hormone is an important and irreplaceable hormone during pregnancy.Abnormal thyroid hormone can cause adverse pregnancy outcomes.More and more laboratory research evidences show that the developments of placenta and fetus are associated with the regulation of thyroid hormone,but there is still no data to translate these laboratory findings into clinical examinations.The purpose of this study was to explore the correlation between maternal thyroid function and placental function by using umbilical blood flow indicators as a mediator,in order to provide clinical data to support laboratory results.Method:The data of 501 pregnant women with regular birth check-ups and deliveries from August 2018 to September 2019 in Shaanxi Provincial People's Hospital Obstetrics were selected for research.Excluding 78 patients with subclinical hypothyroidism,7 patients with hypothyroidism,and 3 patients with hyperthyroidism,the remaining 413 patients are with normal thyroid function.All pregnant women are collected blood through the elbow vein after 12 hours of fasting during pregnancy in People's Hospital of Shaanxi Province Release Center.After measuring the TSH,FT3,FT4 in the serum of pregnant women,the thyroid function index was obtained.The umbilical cord blood flow S / D and RI indexes of all pregnant women during the second and third trimesters were recorded.Record the umbilical cord,placenta condition,newborn growth,weight and score during delivery.By analyzing the index of thyroid function and other indicators such as S / D and IR,the correlation between maternal thyroid function and placental function was explored.Result:(1)There is a statistical difference between TSH in the second trimester and the third trimester compared with the first trimester(P <0.05);there is a statistical difference between the TSH in the second trimester and the second trimester(P <0.05);FT3 in the first trimester,the second trimester and There was no statistical difference between the third trimesters(P> 0.05);FT4 in the third trimesters had statistical differences compared with the first and second trimesters(P <0.05).(2)There is a high positive correlation between RI and S/D in the second trimester(r>0.8,P<0.05);there is a high positive correlation between RI and S/D in the third trimester(r>0.8,P<0.05).(3)There is a positive correlation between RI in the second trimester and FT3 in the first trimester(0.3>R>0;P<0.05),and no correlation with FT3 in the second and third trimester(P>0.05);there is no correlation between RI and TSH and FT4 in the second trimester(P>0.05);There is a positive correlation between S/D in the second trimester and FT3 in the first trimester(0.3>R>0;P<0.05);No correlation between S/D in the second trimester and FT3 in the second and third trimester(P>0.05),no correlation with TSH and FT4 in the first,second and third trimester(P>0.05).(4)There is no correlation between RI and S/D in the third trimester and thyroid markers TSH,FT3 and FT4 in the third trimester(P>0.05).Conclusion:(1)There is a significant correlation between maternal thyroid hormone in early pregnancy and cord blood RI and S / D in second trimester;(2)Maternal thyroid hormone affects the development of placental function during pregnancy;(3)Compared with TSH,TH is more important and lasting in the process of placenta development.