Correlation Analysis Of Thyroid Hormone Levels In Neonatal Heel Blood And Umbilical Cord Blood And Hypothyroidism Of Pregnant Women

Objective:To analyze the correlation between thyroid hormone levels in neonatal heel blood and umbilical cord blood and Hypothyroidism of pregnant women.Methods:The screening results of congenital hypothyroidism in 5,590 neonates who were born in the Second Affiliated Hospital of Kunming Medical University from January 1,2017 to December 31,2017 and the examination results of thyroid function in their umbilicalcord blood and the venous blood of their mother taken within seven days before delivery were analyzed retrospectively.Results:A total of 5590 cases were collected,among which 5130 were registered in Yunnan Province who can be screened for congenital hypothyroidism(CH)in our hospital,and 4592 cases were screened for CH.The screening rate of CH was 89.51%.14 cases of the result of TSH in neonatal heel blood were more than 10mIU/L and the positive deficiency rate was 3.05‰.There are 71 twins and 4521 pregnant mothers.331 cases of pregnant mothers were found to have hypothyroidism during pregnancy,the prevalence was 7.2%.134 cases of neotates met the inclusion criteria of umbilical cord blood collection and umbilical cord blood of 40 cases was collected.The collection rate was 29.85%.Maternal hypothyroidism had no significant effect on the screening results of CH(P>0.05).There was no significant correlation between the TSH in umbilical cord blood and in neonatal heel blood(P>0.05).There was also no significant correlation between the TSH in umbilical cord blood and in venous blood of pregnant women taken within seven days before delivery(P>0.05).There was a statistically significant difference between the TSH in umbilical cord blood and in heel blood(P<0.05).There was a statistically significant difference between the TSH in umbilical cord blood and in venous blood of pregnant women taken within seven days before delivery(P<0.05).There was a significant correlation between the TT4 in umbilical cord blood and in venous blood of pregnant women taken within seven days(P<0.05),the same to the TGAb,the TG and the TPOAb.There was no significant correlation between the TT3 in umbilical cord blood and in venous blood of pregnant women taken within seven days(P>0.05),the same to the FT3 and the FT4.There was a statistically significant difference in the screening results of CH between FT4 normal group and abnormal group(P<0.05).There was no statistically significant difference in the screening results of CH between TSH normal group and abnormal group(P>0.05),the same to the TGAb and the TPOAb.There was no significant difference in the screening results of CH between groups grouped by the specific values or intervals divived equally within the range of normal values of the TSH,FT4 in venous blood of pregnant women taken within seven days(P>0.05).Conclusions:The compliance of the screening for CH in our hospital is good.Maternal hypothyroidism after treatment has no significant effect on neonatal thyroid function.The abnormalities of FT4 of pregnant women before delivery can increase the risk of CH.Keeping FT4 in the normal range before delivery can ensure thyroid hormone level in newborns.