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Association of rs1501299 and rs2241766 single-nucleotide polyorphisms in the adiponectin gene with the risk of polycystic ovary syndrome: a Meta-analysisBackground polycystic ovary syndrome(PCOS)is a common endocrine disorder,and the exact etiology is still unknown.There have been several parallels of research to establish the functional variants of some candidate genes and the risk of PCOS.The adiponectin gene(ADIPOQ)polymorphisms has been implicated in susceptibility to PCOS,but the results remain inconclusive.Objective The results of the ADIPOQ rs1501299 and rs2241766 polymorphisms and PCOS risk remain inconclusive.The aim of this meta-analysis is to evaluate the association between ADIPOQ rs1501299 and rs2241766 polymorphisms and PCOS risk.Methods Databases including Pub Med,PMC,Web of Science,EMbase,Cochrane Library,CNKI,CBM,VIP and Wan Fang were searched from inception to August 2018,and the references of articles were also retrieved to collect case-control studies about the correlation of the rs1501299 and rs2241766 polymorphisms of ADIPOQ and PCOS.According to the self-designed inclusion and exclusion criteria,two reviewers screened articles,extracted data,and assessed the quality of included studies independently.The Stata 12.0 software was used for meta analysis.Results A total of 16 case-control studies involving rs1501299 polymorphism of ADIPOQ were conducted(including 2349 PCOS cases and 3563 healthy controls).A total of 19 case-control studies involving rs2241766 polymorphism of ADIPOQ were included(including 2634 PCOS cases and 4323 healthy controls).Sensitivity analysis without Xita study revealed obvious correlation between rs1501299 polymorphism of ADIPOQ with PCOS in alleles,homozygotes and dominant genetic patterns [T vs.G:OR=0.82,95%CI(0.75,0.90),P=0.000;TT vs.GG: OR=0.64,95%CI(0.51,0.79),P=0.000;TT+TG vs.GG: OR=0.77,95%CI(0.68,0.88),P=0.000].The results did not change after further elimination of HWE's genetic balance study.The results of subgroup analysis after removal of Xita and non-compliance with HWE's genetic balance study showed that rs1501299 polymorphism of ADIPOQ had a correlation with PCOS in Asian populations under different genetic patterns [T vs.G: OR=0.80,95%CI(0.65,0.99),P=0.04;TT vs.GG: OR=0.59,95%CI(0.37,0.95),P=0.031;TT+TG vs.GG: OR=0.76,95%CI(0.64,0.89),P=0.001],but not in the Caucasian populations [T vs.G: OR=0.86,95%CI(0.70,1.05),P=0.145;TT vs.GG: OR=0.85,95%CI(0.54,1.34),P=0.486;TT+TG vs.GG: OR=0.78,95%CI(0.60,1.02),P=0.067].There were no significant differences in rs2241766 polymorphism of ADIPOQ between the case group and control group under alleles,homozygote and dominant genetic patterns[G vs.T: OR=1.12,95%CI(0.90,1.38),P=0.319;GG vs.TT: OR=1.08,95%CI(0.82,1.42),P=0.605;GG+GT vs.TT: OR=0.97,95%CI(0.86,1.10),P=0.671].Conclusions ADIPOQ rs1501299 polymorphism was associated with the risk of PCOS in Asian populations,but ADIPOQ rs2241766 polymorphism was not associated with the risk of PCOS.Part? Correlation between FTO gene Polymorphisms and polycystic ovary syndrome: a Meta-analysisBackground polycystic ovary syndrome(PCOS)is a common endocrine disorder,and the exact etiology is still unknown.There have been several parallels of research to establish the functional variants of some candidate genes and the risk of PCOS.The fat mass and obesity associated(FTO)gene polymorphisms has been implicated in susceptibility to PCOS,but the results remain inconclusive.Objective The results of the FTO gene polymorphisms and PCOS risk remain inconclusive.The aim of this meta-analysis is to research the relationship between FTO gene polymorphisms and PCOS.Methods Databases including Pub Med,Web of Science,EMbase,Cochrane Library,CNKI,CBM,VIP and Wan Fang were searched from inception to November 2018 to collect case-control studies on relationships between FTO gene polymorphisms and susceptibility of PCOS.Paper screening,data extraction and assessment of the quality included studies were carried out.Meta-analysis was then conducted by Stata 12.0 software.Results A total of 15 studies were included.FTO rs9939609(A/T)polymorphism was significantly different between PCOS group and control group in different gene models [A vs.T: OR=1.34,95%CI(1.24,1.44),P=0.000;AA vs.TT: OR=1.68,95%CI(1.37,2.06),P=0.000;AA+AT vs.TT: OR=1.38,95%CI(1.27,1.50),P=0.000;AA vs.AT+TT: OR=1.50,95%CI(1.25,1.82),P=0.000].For FTO rs8050136(A/C)polymorphism studies,only homozygous models [AA vs.CC: OR=1.68,95%CI(1.04,2.71),P=0.035] and recessive models [AA vs.AC+CC: OR=1.68,95%CI(1.06,2.66),P=0.027] had significant differences between the two groups.There were no significant differences in FTO rs1421085(C/T)polymorphism between PCOS group and control group in different gene models [C vs.T: OR=1.10,95%CI(0.93,1.30),P=0.260;CCvs.TT: OR=1.72,95%CI(1.00,2.95),P=0.05;CC+CT vs.TT: OR=1.06,95%CI(0.88,1.27),P=0.554;CC vs.CT+TT: OR=1.69,95%CI(0.99,2.91),P=0.056].Conclusions FTO rs9939609 variation is significantly associated with risk of PCOS.FTO rs8050136 AA genotype may be associated with PCOS.However,FTO rs1421085 polymorphism is not associated with PCOS.Part ? Association between Gln223 Arg Polymorphism in leptin receptor gene and the risk of polycystic ovary syndrome: a meta-analysisObjective To systematically review the association between Gln223 Arg polymorphism in leptin receptor(LEPR)gene and the risk of polycystic ovary syndrome(PCOS).Methods Pub Med,Web of Science,EMbase,Cochrane Library,CNKI,CBM,VIP and Wan Fang Data databases were electronically searched to collect case-control studies on the association between the Gln223 Arg variants of LEPR gene and risk of PCOS from inception to February,2019.Two reviewers independently screened literature,extracted data and assessed the quality of included studies.Meta-analysis was then performed using Stata 12.0 software.Results A total of 8 case-control studies involving 965 patients and 951 controls were included.The results showed that: the Gln223 Arg polymorphism in LEPR gene was not associated with the risk of PCOS[A vs.G: OR=1.15,95%CI(0.83,1.59),P=0.415;AA vs.GG: OR=1.70,95%CI(0.76,3.82),P=0.197;AA+AG vs.GG: OR=1.29,95%CI(0.77,2.17),P=0.333;AA vs.AG+GG: OR=1.07,95%CI(0.75,1.52),P=0.722;AG vs.GG: OR=1.24,95%CI(0.77,2.00),P=0.372].Subgroup analysis showed that,for both Asian[A vs.G: OR=1.11,95%CI(0.58,2.12),P=0.756;AA vs.GG: OR=1.66,95%CI(0.27,10.14),P=0.581;AA+AG vs.GG: OR=1.36,95%CI(0.52,3.53),P=0.530;AG vs.GG: OR=1.30,95%CI(0.57,3.00),P=0.533] and Caucasian[A vs.G: OR=1.11,95%CI(0.86,1.44),P=0.421;AA vs.GG: OR=1.33,95%CI(0.80,2.21),P=0.277;AA+AG vs.GG: OR=1.17,95%CI(0.75,1.83),P=0.482;AG vs.GG: OR=1.14,95%CI(0.69,1.86),P=0.612] subjects,there was no association between the Gln223 Arg polymorphism and susceptibility of PCOS.Conclusion The Gln223 Arg polymorphism is not associated with the risk of PCOS. |
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