Analysis Of The Correlation Among Leptin, Adiponectin And Polycystic Ovary Syndrome

Objective: To investigate the development of polycystic ovary syndrome(PCOS) and theinfluent factors among the leptin(LEP), adiponectin(APN), and to analyse the correlationbetween obesity, and insulin resistance.Methods:Twenty-nine PCOS patients were sampled in experimental group, which were diagnosedaccording to the standard reference to Rotterdam in2003international conference,and38patients with pure tubal factor and/or male factor infertility were randomly assignedas control group. These outcomes including height, weight, BMI calculation, waistcircumference, hip circumference, and waist-to-hip ratio were measured in bothgroup. According to the standard of BMI≥25standard for obesity, the two groups weredivided into obese and non-obese group. The following outcomes were measured in fourgroups,:(1) early follicular phase serum follicle stimulating hormone (FSH), luteinizinghormone (LH), testosterone (T);(2) determination of fasting plasma glucose(FPG), fastingblood insulin(FINS),homeostasis model assessment was applied to assess the status of insulin resistance index(HOMA-IR);(3) the other tube retention after centrifugal blood serum, with doubleantibody sandwich ELISA method for determination of serum LEP, APN, theconcentration of leptin receptor, L/A ratio.Result：（1）The serum LEP levels in PCOS patients were higher than that of the non-PCOSpatients (P=0.001, P <0.05), it show that the serum LEP levels in obesepatients were higher than that of non-obese patients.(2) The serum APN levels in PCOSpatients were lower than that of the non-PCOS patients (P=0.002, P <0.05). The serumAPN levels in obese patients were lower than that of non-obese patients in PCOS patients,but there were no significant difference between groups in non-PCOS patients.(3) The serum L/A ratioes in PCOS patients were significantly higher than that of the non-PCOS patients (P <0.001), it showed that L/A ratioes in obese patients were higher thanthat of non-obese patients.(4) Correlation analysis results: The level of serum LEPwas positively correlated with the level of BMI, WHR and HOMA-IR. The levelof BMI and HOMA-IR were all negatively correlated with the level of serum APN. Thelevel of L/A ratio was positively correlated to the level of BMI, WHR and HOMA-IR.(5)Multivariate regression analysis results: there was no significantly influent factors betweensingle LEP or single APN and PCOS, and the L/A ratio was significantly related withPCOS. So the L/A ratio is superior to single LEP, APN and leptin receptor.Conclusion:LEP, APN may be involved in the occurrence and development of PCOS, and is associatedwith insulin resistance, and is associated with obesity. The L/A ratio is superior to separateserum APN or separate serum LEP. A new index are independent risk factors for thedevelopment of PCOS disease. Increase the LEP level or decrease the APN level, raise theL/A ratio provides a new train of thought for the treatment of PCOS.