Retrospective Study On The Children With Henoch-Schonlein Purpura From 2009 To 2018 In Inner Mongolia People's Hospital

Objectve The purpose of this paper is to retrospectively analyze the clinical data of 726 hospitalized children with Henoch-Schonlein purpura and Henoch-Schonlein purpura in Inner Mongolia People's Hospital from 2009 to2018.to analyze the inducement,pathogenesis,c linical features,diagnosis,treatment and prognosis of Henoch-Schonlein purpura,in order to improve the diagnosis and treatment of Henoch-Schonlein purpura,improve the quality of life,reduce the occurrence of complications and improve the prognosis of children with Henoch-Schonlein purpura.Methods This study selected 726 children with Henoch-Schonlein purpura who were hospitalized in the Inner Mongolia People's Hospital from January2009 to December 2018,including 373 males and 353 females.To collect the clinical data of all hospitalized children with Henoch-Schonlein purpura,including age,sex,nationality,condition,causes(such as infection,food and other stress),past history,chief complaint,evolution of disease,clinical manifestations,exami nation,treatment and prognosis,review,summarize and analyze the data of the patients.The clinical data of the patients were collected and recorded by using the questionnaire,and the clinical data were analyzed systematically,and the data were statist ically analyzed by EXCEL and SPSS 22.0 software.Using the Regression analysis Henoch–Sch?nlein Purpura and respiratory tract infection Linear independence,the counting data were?~2 test,and the measuring data were paired t-test,the ROC curve was used to evaluate the clinical significance of laboratory markers in predicting abdominal HSP gastrointestinal bleeding,and the area under the ROC curve(AUC)was used to evaluate the area under the curve and the Best cut-off point.The area under the curve is AUC according to the following criteria:AUC?0.5:inaccuracy;0.5<AUC?0.7:Low Accuracy;0.7<AUC?0.9:medium accuracy;0.9<AUC<0.1:High Accuracy;AUC=1:gold standard.All statistical tests were performed with P<0.05 was considered statistically significant.Results1.Among the 726 children with HSP,there were 373 males and 353 females,with a male-to-female ratio of 1.05 percent,there were 604 Hannationality,314 males and 290 females,and the male-female ratio was 1.08:1;Mongolian nationality had 108 cases,53 males and 55 females,and the male-to-female ratio was 1:1.04.The youngest age of onset was 3 months,the maximum was17 years old,and the average age was 7.6±2.1 years old.2.There were 209 cases(28.79%)in spring,166 cases(22.87%)in summ er,143 cases(19.70%)in autumn,and 208 cases(28.65%)in winter,and frequent in winter and spring.The incidence of HSP is decreasing year by year.3.There were 506 cases(69.70%)of respiratory tract infection,31 cases(4.26%)of digestive tract infect ion,6 cases(0.08%)of urinary tract infection and 4 cases(0.05%)of skin infection before and during the onset of Henoch-Schonlein purpura.18 cases(1.10%)had advanced special food(seafood,mango,tomato),and 151 cases(21.25%)had no obvious inducement.There was a positive linear correlation between the number of children with Henoch-Schonlein purpura and the number of patients with respiratory tract infection(r=0.885,p<0.01).4.In HSP of the children,the main joints involved were knee joint and ankle joint,wrist joint and elbow joint were less involved,and one case could involve the phalangeal facet joint.5.There was significant difference in NLR and PLT between renal involvement group and non-renal involvement group(p<0.05),but there was no significant difference in WBC and PLT between renal damage group and non-renal damage group(p>0.05).The AUC values of NEU,NLR and WBC were 0.954,0.884 and 0.830,respectively,all of which were more than 0.7,which could be used to predi ct abdominal Henoch-Schonlein purpura complicated with gastrointestinal bleeding.6.710 cases of HSP were improved and cured(97.80%),13 cases were not cured and discharged from hospital(1.79%),and 3 cases were not cured and transferred to hospital(0.41%).Conclusion1.The peak incidence of Henoch-Schonlein purpura was 9 years old,and there was no significant difference between male and female.There was no significant difference in renal injury between Han and Mongols HSP children(p<0.05).2.The incidence of Henoch–Sch?nlein Purpura has been decreasing year by yearin Inner Mongolia People's Hospital;3.Respiratory tract infection is the most common cause of Henoch-Schonlein purpura,and there is a positive linear relationship between HSP incidence and respiratory tract infection in each month.4.NLR and PLT may be predictors of renal involvement.5.NEU,NLRand WBC have predictive value for abdominal Henoch-Schonl ein purpura complicated with gastrointestinal bleeding.6.The prognosis of children with allerg ic purpura is good,and only a small number of children affect the prognosis due to the involvement of important organs.