Retrospective Analysis Of Clinical Characteristics And Risk Factors Of Primary Liver Cancer

Objective Retrospectively analyze the clinical medical records of patients with primary liver cancer in our hospital,systematically summarize the characteristics of the incidence of liver cancer and its risk factors,improve people's understanding of the disease,and provide a certain basis for the prevention,early diagnosis and prognosis of liver cancer in our district Theoretical basis.Methods The search time span from 2010.1 to 2019.12 was searched by our hospital's big data network platform and medical record room system with keywords such as "liver malignant tumor","primary liver cancer","hepatocellular carcinoma",and "liver cancer".In-patients were selected from those who met the three criteria of primary liver cancer diagnostic criteria,relatively complete clinical data,and the first confirmed diagnosis.The age,gender,occupation,first symptoms,smoking history,drinking history,and previous combined medical history of the patients were collected.,Family genetic medical history,hepatitis virus markers(mainly HBV,HCV),blood routine,biochemical examination results,tumor marker results,imaging examination and other clinical data,and simultaneously collect clinical data of patients with chronic hepatitis and cirrhosis as For comparison,establish an Excel statistical table,and then use the relevant statistical software for data analysis.Result 1.General situation: Of the 428 patients diagnosed with primary liver cancer for the first time in our hospital,346 were male(80.84%)and 82(19.16%)were female.The male-to-female ratio was 4.22: 1,with an average incidence.The age of male(57.11 ± 10.12)was smaller than that of female(62.54 ± 9.38),and the difference was statistically significant(t =-4.429,P <0.001).The number of people with the outbreak was 51-70 years old,accounting for 63.55%;the occupational distribution was mainly Farmers,workers,and unemployed workers(accounting for about 70%),the first clinical symptoms are mainly abdominal distension,abdominal pain,fatigue and poor appetite,accounting for about 60%,and 15.65% of patients have no significant discomfort.2.Hepatitis markers: 352 cases of HBV-M(+)(82.24%),with the most HBe Ag-negative cases,323 cases(91.76%),and“Hepatitis B small three positives” accounted for 39.49%(139/352),and Only 29 cases(8.24%)were positive for HBe Ag;62.22%(165/261)of HBV-DNA test results> 500 copies /ml,the positive rate of big three positives(22/26)was greater than that of small three positives(77/139),both rates The difference was statistically significant(X2 = 5.634,P<0.05);22 cases of HCV-M(+),the positive rate of HCV-RNA detection was 90%(18/20).3.Tumor markers: AFP,CA125,CA199,CEA and ferritin test positives accounted for 66.75%,56.06%,32.55%,15.07%,56.31% respectively;various tumor markers were in the liver cancer and cirrhosis groups The difference between AFP(X2 = 166.269,P <0.001)and ferritin(X2 = 14.825,P <0.001)was statistically significant.The positive rates of ferritin detection were different in the AFP(+)and AFP(-)groups,and the differences were statistically significant.Significance(X2 = 5.671,P <0.05).4.Laboratory examination: There was no statistically significant difference between the NEUT groups(P> 0.05);the differences between WBC,MO,HCT,MPV,LY,RBC,HGB,PLT,PDW,and PCT were statistically significant(P <0.05).Pairwise comparisons between groups Shows that MO,LY,PCT,MPV have statistical significance in liver cancer group and chronic hepatitis group,RBC,HGB,HCT,PLT have statistical significance in liver cancer group,cirrhosis and chronic hepatitis group;AST increased(72.2%)was significantly higher than ALT(56.31%),81.54% of patients showed elevated GGT,especially those who drank alcohol(139/166),and those with elevated bilirubin accounted for DBIL The highest was 71.96%.5.Logistic regression analysis showed that the risk factors of HBV-related PHC were alcohol consumption(OR = 7.791),HBe Ag infection(OR = 5.341),HBV-DNA positive(OR =6.684),family history of liver cancer(OR = 8.874),and age(OR = 0.960).Conclusion 1.Hepatitis B-related liver cancer accounted for the largest proportion of primary liver cancers in this region in the past 10 years.The number of males is far more than that of females,and the average age of onset is lower than that of women.HBe Ag is mainly negative,and the main first symptoms are abdominal distension,abdominal pain,fatigue,anorexia,etc.The tumor markers have the highest AFP positive rate.2.Age,drinking,HBe Ag-positive infection,HBV DNA replication,and family history of liver cancer may be risk factors for HBV-related primary liver cancer in the region.