Mutiviate Regression Analysis Of Risk Factors For HBV-related Primary Liver Cancer

Objective To explore the correlation between HBV-related primary liver cancer and HBV DNA level, HBeAg and other risk factor. To explore clinical features of patients with HBeAg-negative chronic hepatitis B(CHB).Methods A case-control study was carried out. Retrospective analysis of merger of243cases of HBV-related primary liver cancer and227cases of chronic hepatitis B in Qingdao Infectious Disease Hospital from February2010to June2012. Name, sex, age, occupation, the natural history of hepatitis B virus, drinking history, family history of hepatitis B virus, family history of cirrhosis, family history of liver cancer, HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HBV-DNA (after admission and before discharge), blood routine (RBC, WBC, PLT, HGB), TBil, ALT, AST, r-GTT, Alb, AFP, CEA, imaging (B ultrasound, CT) were enregistered. Statistical analyses were performed using the SPSS17.0. Retrospective analysis of merger of227cases of hospitalized CHB in Qing dao Hiser Hospital from February2010to June2012., and were divided into HBeAg-positive and HBeAg-negative groups. Age, duration of disease, HBV DNA and hepatic function were compared between the two group.Results Within the two groups, male, drinking history, antiviral history, family history of hepatitis, liver cancer family history, family history of liver cirrhosis, HBeAg-negative, HBV DNA-positive proportion was81.89%,33.74%,53.50%,34.16%,17.28%,11.93%,74.19%,63.39%and66.08%,13.66%,59.03%,33.04%,7.49%,4.41%,55.95%,53.81%. In addition to anti-virus history, family history of hepatitis, sex, drinking history, family history of liver cancer, cirrhosis family history, HBeAg, HBV DNA has a statistically significant difference. The logistic regression analysis indicated that age, sex, drinking history, family history of liver cancer, cirrhosis family history, HBeAg, HBV DNA showed significant difference between case group and control group.101cases of HBeAg-positive CHB accounting for44.49%, whose average age were [53.0(48.5,57.0)]yeas old;126cases of HBeAg negative CHB accounting for55.51%, whose average age were [55.5(51.0,61.0)]yeas old. There was a significant diference in average age between HBeAg-positive and HBeAg-negative patients with CHB(P=0.002). The duration of disease in HBeAg-negative group was12.5(7.0,20.0)years, longer than that in HBeAg-positive group10.0(4.0,17.5) years]; The positive rates of H BV DNA in HBeAg positive group was significantly higher than in HBeAg-negative group ((χ2=25.63, P=0.000); The HBV DNA loads of HBeAg-negative and HBeAg-positive patients with CHB had statistically significant difference (χ2=43.573, P=0.000). There was no statistically signficant in hepatic function between HBeAg-negative and HBeAg-positive patients with CHB. respectively).Conclusion We concluded that HBV-related primary liver cancer was related to age, sex, drinking history, family history of liver cancer, cirrhosis family history, HBeAg, HBV DNA. The average age and duration of disease of HBeAg-negative patients with CHB are higher than HBeAg-positive patients. The HBV DNA loads in HBeAg-negative patients with CHB are lower than HBeAg-positive patients.