Clinical Study On Massage Of Emeishangke School In Treating Delayed Pain After Intra-articularly Injection Of Mesenchymal Stem Cells In Patients With Knee Osteoarthritis

Objective: Mesenchymal stem cells are gradually becoming a choice for the treatment of knee osteoarthritis.However,we still lack basic understanding and effective intervention on the delayed pain after intra-articularly injection of mesenchymal stem cells,which is the most common adverse reaction of the treatment of mesenchymal stem cells intra-articularly injection.In this study,patients with knee osteoarthritis who received intra-articular injection of mesenchymal stem cells were selected as subjects to describe the clinical characteristics of delayed pain after intra-articular injection of mesenchymal stem cells.The effects of massage of Emeishangke school and routine postoperative nursing guidance on delayed pain after intra-articular injection of mesenchymal stem cells were compared.The purpose of this study is to explore the possible clinical ideas and methods of TCM intervention on delayed pain after intra-articular injection of mesenchymal stem cells.Methods: This study is divided into two parts.The first part is the previous study,which retrospectively describes the clinical characteristics of delayed pain after intra-articular injection of mesenchymal stem cells.The second part is a randomized controlled clinical trial to compare the effects of the massage of Emeishangke school and routine postoperative nursing guidance on delayed pain after intra-articular injection of mesenchymal stem cells.1.The medical records of 7 patients with knee osteoarthritis who received intra-articular injection of mesenchymal stem cells were reviewed,and their sex,age,medical history,signs,imaging examination(knee joint MRI),treatment,time and duration of delayed pain,nature and degree of pain described by patients,concomitant symptoms,etc.,were analyzed.To describe the clinical characteristics of delayed pain after intra-articular injection of mesenchymal stem cells.2.Ten patients with knee osteoarthritis who received intra-articular injection of mesenchymal stem cells were randomly divided into treatment group(n = 5)and control group(n = 5).The treatment group received Emei Traumatology School manipulation treatment immediately after injection,and then Emei Traumatology School manipulation treatment once a day for 4 consecutive days,while the control group was given bed rest for 30 minutes after injection and postoperative nursing guidance that could not bear weight within 3 days.The most severe pain intensity in the past 24 hours was measured every day within 4 days after treatment(VAS)to compare the average change of pain intensity between each group and the baseline,the average pain duration,the time of complete pain relief,the most severe pain intensity within 14 days and the incidence of adverse events in each group,in order to evaluate the clinical efficacy of the massage of Emeishangke school in the treatment of delayed pain after intraarticular injection of mesenchymal stem cells.Results: 1.Among the 7 patients,there were 3 males and 4 females,5 patients described the pain as "distending pain",2 patients could not describe the pain,2 patients complained of knee joint swelling,1 patient complained of knee joint fever and discomfort,the interval between pain occurrence and injection was(5.3 ±1.8)hours,and the pain duration was 0.5 ~ 3 days,with an average duration of(1.8 ±1.0)days.Among the 7 patients,4 cases had severe pain,2 cases had moderate pain,1 case had mild pain,and no patient used painkillers.2.There was no significant difference in sex,age,VAS and course of disease between the two groups before treatment.The results suggested that the baseline of the two groups was comparable.After treatment,there was no significant difference between the two groups in the main curative effect index(VAS)and the secondary curative effect index(pain duration).Conclusion: 1.We found that the main clinical manifestation of delayed pain after intra-articular injection of mesenchymal stem cells was local pain in the knee joint,and most of the pain was swelling pain,which may be accompanied by symptoms such as local swelling and fever of the joint.It usually appeared 4-6 hours after injection and relieved spontaneously after 0.5-3 days.2.Patients with delayed pain after intra-articular injection of mesenchymal stem cells received the massage of Emeishangke school and routine nursing guidance,there was no significant difference in pain intensity and pain duration within 3 days.The clinical effect of the massage of Emeishangke school on delayed pain after intra-articular injection of mesenchymal stem cells needs to be verified by a larger sample clinical study.