| Objective: Chronic central serous chorioretinopathy is a chronic central serous chorioretinopathy(CSC)characterized by diffuse pigment epitheli?m damage,which leads to permanent decline or even disappearance of visual acuity.This study mainly discusses the TCM constitution distribution characteristics and macular OCT pathological changes of chronic CSC,in order to provide a certain clinical basis for the use of TCM theory to correct biased constitution.Methods: 41 patients with central serous chorioretinopathy were divided into two groups according to the type of CSC.Group A was acute chronic CSC and group B was chronic CSC.The sex,age,n?mber of affected eyes,macular choroid thickness(horizontal and vertical thickness average),macular retinal neuroepithelial thickness,macular photoreceptor layer injury ratio(horizontal / vertical),macular neuroepithelial detachment ratio(horizontal / vertical)and TCM constitution distribution were observed in the two groups.Results:(1)Gender difference: in this study,there were 27 males and 14 females in41 patients with CSC.There were 14 males and 7 females in group A and 13 males and 7 females in group B.In the gender distribution,there was no significant difference between the two groups(P>0.05).(2)Age distribution: in group A,10 cases were less than or equal to 40 years old,constituent ratio was 47.6%,11 cases were greater than 40 years old,constituent ratio was 52.4%,6 cases were less than or equal to 40 years old,accounting for 30%,14 cases were greater than 40 years old,accounting for 70%.There was no statistical difference between the two groups(P>0.05).(3)Distribution of the n?mber of affected eyes: in group A,there were 20 cases of monocular disease,constituent ratio 95.2%,binocular disease 1 case,constituent ratio4.8%.In group B,the n?mber of monocular disease was 16 cases,constituent ratio80%,binocular disease 4 cases,constituent ratio 20%,there was no statistical difference between the two groups(P>0.05).4)Choroidal thickness in macular region: 22 affected eyes in group A with an average choroidal thickness of 386.11 ±115.26?m,20 healthy eyes in group A with an average choroidal thickness of 252.45 ±84.16?m;24 affected eyes in group B with an average choroidal thickness of 321.85 ±70.32?m,16 healthy eyes in group B with an average choroidal thickness of 241.81±62.01?m;The results showed that there was significant difference between the affected eyes of group A and the affected eyes of group B(P=0.026<0.05).There was significant difference between the affected eyes of group A and the healthy eyes of group A(P<0.001).There was significant difference between the affected eyes of group B and the healthy eyes of group B(P<0.001).There was no significant difference between healthy eyes in group A and healthy eyes in group B(P>0.05).5)The macular retinal neuroepithelial thickness: the macular retinal neuroepithelial thickness was 194.59 ±52.66 mm in group A and 162.63 ±37.33 mm in group B.there was significant difference between the two groups(P=0.031<0.05).6)The ratio of photoreceptor damage to neuroepithelial detachment was 1.09 ±0.15 in group A,0.89 ±0.21 in group B,and there was significant difference between the two groups(P =0.01<0.05).The ratio of neuroepithelial detachment in A group was 1.05±0.15,0.94 ±0.31 in group B,and there was no significant difference between the two groups(P>0.05).(7)Physique distribution of traditional Chinese medicine: in group A,the physical distribution of phlegm and dampness was 47.6% in 10 cases,qi-stagnation was 14.3%in 3 cases,normal was 9.5% in 2 cases,yang deficiency was 9.5% in 2 cases,qi deficiency was 4.8% in 1 case,yin deficiency was 4.8% in 1 case,damp-heat was4.8% in 1 case and blood-stasis was in 1 case.In group B,the constitution distribution of traditional Chinese medicine was qi depression(60%),phlegm-dampness(15%),normal(2 cases),qi deficiency(2 cases),yang deficiency(1 case)and yang deficiency(5%).No yin deficiency,damp-heat,blood stasis and special were collected.There was mainly qi depression in group A and phlegm-dampness in group B.There was significant difference between the two groups(P>0.05).Conclusion:The main results are as follows: 1.Patients with CSC are more likely to be male.2.There is no significant difference in the incidence of monocular and binocular disease between patients with chronic CSC and patients with acute CSC.3.The macular choroidal thickness of chronic CSC eyes was thinner than that of acute CSC eyes,and the choroidal thickness of chronic and acute CSC eyes was significantly thicker than that of contralateral healthy eyes,suggesting that there may be a general increase in choroidal blood flow in CSC eyes,and there may be a decrease in choroidal circulation blood flow or choroidal capillary atrophy in chronic CSC eyes compared with acute CSC eyes.4.The thickness of macular neuroepithelial retina in chronic CSC is thinner than that in acute CSC,indicating that there is damage to the structure of retina in patients with chronic CSC,which can lead to degenerative change for a long time.5.The degree of photoreceptor damage in chronic CSC is more severe than that in acute CSC,and the length of photoreceptor damage in vertical position is generally larger than that in horizontal position in patients with chronic CSC,suggesting that there is a downward trend in the vertical position of macula in patients with chronic CSC.6.The TCM constitution distribution of chronic CSC is mainly qi depression,while that of acute CSC patients is phlegm-dampness. |
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