| Objective: To investigate the effects of Jiawei Baihu Ginseng Decoction on blood glucose,blood lipid,body weight,BMI,TCM syndromes and other related indexes in patients with type 2 diabetes(T2DM)stomach heat syndrome,and explore the effect of Jiawei Baihu Ginseng Decoction on stomach fever The effectiveness of T2 DM treatment provides certain ideas and methods for T2 DM synergy in the treatment of T2 DM,improving clinical symptoms and improving the quality of life of patients.Methods: This study was a randomized,parallel controlled trial.The 66 patients with T2 DM stomach fever syndrome who met the inclusion criteria would be randomly divided into a treatment group and a control group.In addition to basic treatments(health education,diet control,exercise),the control group was given metformin hydrochloride tablets and acarbose tablets;the treatment group was given an oral Chinese medicine "Jiawei Baihu Ginseng Decoction" on the basis of the control group.After 8 weeks of observation,fasting blood glucose(FPG),2-hour postprandial blood glucose(P2h PG),glycated hemoglobin(Hb Alc),cholesterol(TC),triglyceride(TG),and high-density lipoprotein(HDL-C)were recorded before and after treatment in the two groups of patients.low-density lipoprotein(LDL-C),weight,BMI,TCM syndrome score and other indicators.SPSS 26.0 software was used for statistical analysis of the data.Result:(1)Evaluation of TCM efficacy: After treatment,the TCM syndrome scores of both groups decreased,of which the treatment group decreased by 10.26 ± 2.18 points and the control group decreased by 3.78 ± 0.52 points.The total effective rate in the treatment group was 96.77%,and the total effective rate in the control group was about 50%.Compared with the two groups,the total effective rate of the treatment group is higher and better than that of the control group,and these differences had obviously significance in statistics.(P <0.01).(2)Glycemic index: After treatment,FPG,P2 h PG and Hb A1 c indexes of the two groups of patients decreased significantly after treatment,and the difference was statistically significant(P <0.01).The treatment group's FPG,P2 h PG,and Hb A1 c were significantly improved compared with the control group.And the differences had obviously significance in statistics(P <0.01).(3)Blood lipid index: After treatment,TC,TG and LDL-C in the two groups decreased,HDL-C increased compared with before treatment,with significant difference(P <0.01).TC,TG,HDL-C,and LDL-C in the treatment group were significantly improved compared with the control group,with the statistically significant differences(P <0.05).(4)Weight and BMI indicators: After treatment,the body weight and BMI of the two groups decreased compared with the previous ones,and these differences had obviously significance in statistics(P <0.01).After the treatment,there was no obviously significant difference between the two groups(P> 0.05)..(5)Adverse reactions: mild adverse reactions occurred during treatment.In the treatment group,1 case had diarrhea,1 case had an increase in qi,and 0 cases had nausea and hypoglycemia.The total probability of adverse reactions was 6.45%.In the control group,there was 1 case of abdominal distension,1 case of diarrhea,2 cases of increased qi,and 0 cases of hypoglycemia.The total probability of adverse reactions was 12.50%.(6)Safety indicators: Before and after the treatment,the two groups' vital signs of subjects were stable,and there were no obviously differences in blood routine,urine routine,stool routine,liver and kidney function,electrolyte,electrocardiogram and other inspection and examination indexes,and they remained within the normal range.Research conclusions: Under the guidance of Professor Yue Rensong's theory of "Third Stages of Syndrome Differentiation of Thirst",it was found that the syndrome of hot stomach fever is one of the important types of early thirst.The treatment of Jiawei Baihu Ginseng Decoction combined with western medicine can improve the TCM syndromes of patients obviously,and at the same time can synergistically control blood sugar and improve glucose and lipid metabolism.The combination of traditional Chinese and western medicine also has a certain effect on weight loss and BMI.At the same time,the combination of traditional Chinese and western medicine can significantly reduce the adverse reactions of patients after taking western medicine,maximize the effect of reducing blood sugar,and minimize the adverse reactions.It has certain advantages for patients who have elevated blood glucose and overweight or obesity due to inadequate diet in the early stage of thirst,which deserves further research and promotion. |
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