Relationship Between Preterm,Low Birth Weight And Early Childhood Caries

Background and aim: This project systematically analyzed the relationship between preterm,Low Birth Weight(LBW)and Early Childhood Caries(ECC)in the way of evidence-based medicine.The results of this meta-analysis provided scientific evidence for the etiology and prevention of ECC.Method: After searching database and manual retrieval,case-control and cross-sectional studies relevant to the relationship between preterm,LBW and ECC up to December 2019 were included.The retrieval database included:CNKI,wanfang,VIP,Pub Med,Wiley,Cochrane library,Science Direct,Web of Science.The JBI and NOS scales were adopted to evaluate the quality of cross-sectional and case-control studies,respectively.The Q test was used to assess the heterogeneity.Potential publication bias was detected by Peters' test.The data about Odds Ratio(OR)and 95% Confidence Interval(95% CI)were extracted and dealt with STATA 14.0 software.Result: A total of 22 related studies were included in this meta-analysis.In which there were 9 studies explored not only the relationship between ECC with preterm but also the relationship between ECC with LBW.There were 7studies observed the relationship between preterm with ECC and 6 studies investigated the relationship between LBW and ECC.The results of this meta-analysis showed that the preterm increased the risk of ECC(OR=1.59,95% CI 1.36-1.87)significantly.There was no difference between LBW and normal birthweight in the incidence of ECC(OR=1.12,95% CI 0.94-1.33).The meta-analysis result of adjusted OR about LBW was similar to the crude OR(OR=1.05,95% CI 0.71-1.57).Conclusion: This meta-analysis indicated that preterm increased the risk of ECC significantly;however,LBW was not a risk factor for ECC.