| Objective This study investigated the incidence of gestational diatebes mellitus(GDM)and related high-risk factors by affiliated hospital of Inner Mongolia Medical University(hereinafter referred to as our hospital),proposed corresponding preventive measures for different high-risk factors,guided disease monitoring and early intervention Provide reference for the prevention and control of GDM in this area.Methods From October 2018 to October 2019,107 GDM pregnant women who were hospitalized and delivered in our hospital with regular birth checkups were selected as the case group,and 107 normal pregnant women during the same period were selected as the control group.The general data,current medical history,family history,nutritional pattern during pregnancy,and pre-archive examination results were collected in case and control groups,and the results were analyzed by SPSS 20.0(SPSS Inc.,Chicago,USA)software.The measurement data are described by(mean ± standard deviation)or(median,interquartile range).The normality test uses the one-sample KS goodness-of-fit method.The comparison of the two groups of means uses the t test.The comparison of multiple groups of means was performed by analysis of variance,and the comparison between groups that did not obey the normal distribution used the rank sum test.Count data is statistically described by rate,and statistical inferences are performed by χ2 test.Multi-factor two-category non-conditional logistic stepwise regression analysis was used to screen the factors affecting the occurrence of GDM.For statistical analysis,a two-sided test was used.The significance test level was α =0.05.P <0.05 indicated that the difference was statistically significant.Results(1)The total number of pregnant women giving birth in our hospital from October 2018 to October 2019 was 2997,of which 204 were diagnosed with GDM.(2)(1)In the general data of the GDM group,the age,body mass index(BMI)before pregnancy,weight gain during pregnancy,education,type of work,pregnancy,parity,number of abortions,pre-pregnancy check,pregnancy method,and pregnancy Compared with the normal group,there were significant differences in history,family history of diabetes,and the normal group(P <0.05),but there was no significant difference in the ethnic group,menarcheage,menstrual disorders,history of dysmenorrhea,early pregnancy diet,and twins compared with the normal group.Sex(P> 0.05).(2)In the laboratory test results of the GDM group,white blood cells(WBC),red blood cells(RBC),total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL-C),high density lipoprotein(HDL-C),fasting blood glucose in early pregnancy(FPG),calcium ion concentration,hemoglobin(HB),C-reactive protein(CRP),fibrinogen(Fib),and free T4(FT4)were significantly different(P <0.05),while platelets(PLT)),Hematocrit(HCT),mean platelet volume(MPV),thyroid stimulating hormone(TSH),free T3(FT3),aspartate aminotransferase(AST),Alanine aminotransferase(ALT),International Normalized Ratio(INR),blood type and other aspects compared with the normal group,there was no significant difference(P> 0.05).(3)(1)Univariate Logistic regression analysis found that age,BMI before pregnancy,weight gain during pregnancy,college education or above,sedentary work and unemployed,prenatal pregnancy check-ups,pregnancy ≥ 2 times,pregnant women,abortion times ≥ 2 Second,pregnancy history,pregnancy history and family history of diabetes are all related factors of GDM(P <0.05),whilemenarche age,ethnicity,menstrual disorders,dysmenorrhea,conception of pregnancy,early pregnancy eating habits,abortion once,twins There was no effect on the incidence of GDM(P> 0.05).(2)Laboratory test results of single factor logistic regression analysis found that WBC,RBC,TC,TG,LDL-C,HDL-C,calcium ion concentration,fasting blood glucose in the first trimester,CRP,HB,Fib,etc.were all related factors of GDM(P <0.05),while PLT,HCT,MPV,TSH,FT3,FT4,AST,ALT,INR,and blood type had no effect on the incidence of GDM(P> 0.05).(4)Multivariate Logistic regression analysis found that sedentary work(OR = 7.732,95% CI:2.100-28.412),pregnancy history during pregnancy(OR = 11.229,95% CI: 3.176-36.695),RBC(OR = 9.517,95% CI: 2.510-36.081),CRP(OR = 2.281,95% CI: 1.387-3.750)LDL-C(OR = 10.779,95% CI: 4.518-25.716)is a high risk factor for GDM,and the education level is Technical secondary school(OR = 0.038,95% CI: 0.004-0.350)and bachelor degree or above(OR = 0.032,95% CI: 0.003-0.391)are the protective factors of GDM(P <0.05).(5)The incidences of other complications during pregnancy,cesarean section,premature babies,and babies in the GDM group were significantly higher than those in the normal group(P <0.05).Conclusion In this study,the incidence of GDM in our hospital from October 2018 to October 2019 was 6.81%(204/2997),which was lower than the total incidence of GDM inChina 14.8% [1],but it was at a moderate level of GDM in China(1 % To 33%)[2].Among them,sedentary work,pregnancy history during pregnancy,RBC,CRP,LDL-C are high risk factors for GDM,and education is a protective factor for GDM(P <0.05).GDM increases the incidence of other complications during pregnancy,cesarean section,premature babies,and babies.Strengthen the management of pregnant women with high-risk factors during early pregnancy and conduct blood glucose intervention as early as possible.Oral glucose tolerance test(OGTT)is performed at 24 to 28 weeks of gestation.OGTT results are tracked in time to control blood glucose as early as possible to reduce complications during pregnancy.Adverse pregnancy outcomes. |
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