The Changes Of Atrial Structure And Function And BNP Level After RFCA Of Idiopathic Frequency Premature Contractions Of Different Origins

Object:To evaluate the changes of function of left and right atrium and BNP level after radiofrequency catheter ablation(RFCA)and the influence of different original frequent premature ventrieular contractions(PVC)on left and right atrial function before and after RFCA.Methods:A total of 62 inpatients with frequent PVC observed on 24 h Holter monitoring(>10%)and successful radiofrequency ablation were included in this study in the Second Hospital of Hebei Medical University from Mar.2018 to Nov.2019.Among them 23 patients with frequent PVC originated from the left ventricle and 39 originated from the right ventricle.Function of Left and right atrial and BNP level were measured by echocagdiography and BNP quantitative detector before RFCA and after RFCA at 1 day,1month,3month and 9month(±3month),collecting 32 healthy people in the same time,to investigate whether there was a difference between groups.Result:1.Left atrial diamete(LAD)in right ventricle group and left ventricle group before RFCA were significantly higher than those in control group,while LAD in right ventricle group and left ventricle group were decreasing in 9 month(±3month)after RFCA.2.Right atrial ejection fraction(RAEF)in right ventricle group and left ventricle group before RFCA were significantly lower than those in control group.Meanwhile,RAEF in right ventricle group after RFCA was gradually improved.3.With the significant reduction in PVC load after surgery in both treatment groups,the left atrial strain in the groups was significantly higher than before surgery,and S,SRe,and SRa in the right ventricular source group were significantly higher than those in the left ventricular source group.4.brain natriuretic peptide(BNP)in right ventricle group and left ventricle group before RFCA were significantly higher than those in control group,while BNP in right ventricle group and left ventricle group were decreasing in 9 month(±3month)after RFCA.Conclusion:1.Simple frequent ventricular premature beats can increase the diameter of the left atrium,significantly reduce the strain of the left and right atria,the diameter and strain could gradually improve after radiofrequency ablation.Besides the right ventricle-derived ventricle has a significant effect on the left atrium,and left ventricle-derived ventricle has a significant effect on the right atrium.2.Frequent ventricular premature beats potentially increase plasma BNP levels in patients with normal cardiac function,and reduce plasma BNP after effective catheter ablation treatment.Plasma BNP maybe used to evaluate the severity,development and prognosis of patients with ventricular premature contraction.