Radiofrequency Catheter Ablation For Frequent Ventricular Premature Contractions Guided By Tri-dimensional Electroanatomical Mapping System

Objective: The aim of the study was to assess the clinical efficacy of radiofrequency c-atheter ablation for frequent ventricular premature contractions(PVC) guided by Tri-di-mensional electroanatomical mapping system(Carto3). And compared the changes of c-oncentration of NT-proBNP in plasma and the structure of heart.Methods: The study included forty-seven patients who underwent catheter ablation forPVC from2011to2013. All the patients were divided into conventional mapping group(n=17) and tri-dimensional group(n=30). The measured indices included the time of op-eration, X-ray exposure time, the number of discharges, short-term success rate, long-te-rm success rate. We also compared the changes of concentration of NT-proBNP in plas-ma, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter(LVEDd) after ablation.Results: Compared the tim-e of oprating procedure[(142.71±13.12) min vs (90.13±24.65) min], the time of X-ray exposur [(37.22±14.10) min vs (8.47±2.07) min], the discharge times [(8±2.52) vs (2.82±1.29)] between the conventional mapping group and tri-dimensional group, all of thesd had show significant change. But the short-term (82.35%vs93.33%) and long-term(76.47%vs86.67%) success rate had non-significant ch-age(P<0.05). NT-proBNP concentration in the control group was (7.24±2.03) pg/ml, LVEDd and LVEF values was (42.25±3.28) mm,(64.08±4.45)%. Before the ablation in case group was (8.38±3.77) pg/ml,(43.49±3.42) mm,(63.24±4.79)%. After t he ablation in the case group (8.09±2.74) pg/ml,(42.86±2.73) mm,(63.57±4.81)%.Compared with one another, the NT-proBNP concentrations, LVEDd and LVEF werenot statistically different (P>0.05).Conclusion: The Carto3electroanatomical mapping system, referred to the electrophy-siologic data and reconstructed a tri-dimensional structure of the heart, can quickly loca-te the point of origin of PVC by using of activation mapping and pace mapping technol-ogy. And the Carto3system can improve ablation target position accurate, with a moreh-igh short-term and long-term success rate, and make the time of oprating procedureshorter, X-ray exposure time shorter, less number of discharge. Compared with conven-tional mapping, radiofrequency catheter ablation of PVC under Carto3is more safe an-d effective. PVC can affect NT-proBNP levels and cardiac structure with non-significa-nt downward trend after the ablation, but there is no statistical difference.