A Single-center Study Of CT-guided Percutaneous Biopsy In Small Pulmonary Nodules

In recent years,with the emphasis on physical examination and the widespread clinical application of low dose chest CT,the detection rate of pulmonary nodules is getting higher and higher.For small nodules with diameter of ? 1cm in pulmonary,early identification of pathological diagnosis is of great significance for clinical treatment and patient prognosis.CT-guided percutaneous pulmonary biopsy,as a minimally invasive interventional surgery,is widely used in hospitals at all levels because of its high safety,high accuracy,simple operation and less pain.However,there are few reports on the value of puncture biopsies for small nodules.ObjectiveThrough a single-center study,the purpose of this study was to retrospectively analyze the clinical data of 75 patients with small pulmonary nodules,guided by CT,and to explore the accuracy,clinical application value and complications of percutaneous biopsies in the diagnosis of small pulmonary nodules.Materials and methodsThe clinical data of 75 patients with small pulmonary nodules(long diameter of? 1cm)guided by CT in the affiliated Cancer Hospital of Nanjing Medical University from January 2015 to December 2017 were analyzed retrospectively.Among the biopsies,there were 65 patients in the Fine-Needle Aspiration group and 10 patients in the Core-Needle Biopsy group.The diagnostic sensitivity,accuracy and common complications of the two biopsies were analyzed.ResultsThe puncture sensitivity and accuracy of Fine-Needle Aspiration group were71.4%(35/49)and 72.3%(47/65),those of Core-Needle Biopsy group were 85.7%(6/7)and 80.0%(8/10).There was no significant difference between the two groups(P>0.05).The incidence of bleeding in the adjacent lung field was 25.0% in Core-Needle Biopsy group which was significantly higher than that in Fine-Needle Aspiration group(4.3%).The difference was statistically significant(P<0.05).The incidence of pneumothorax,needle bleeding and subpleural hematoma were 50.0%,41.7%,16.7% in Core-Needle Biopsy group,and 24.6%,47.8%,1.4% in Fine-Needle Aspiration group where showed no significant difference(P>0.05).ConclusionCT-guided percutaneous Fine-Needle Aspiration and Core-Needle Biopsy were sensitive and accurate in diagnosis of small pulmonary nodules.There was no significant difference in sensitivity and accuracy between Fine-Needle Aspiration and Core-Needle Biopsy.Small pulmonary nodules percutaneous biopsy has a low incidence of serious complications and high safety.The incidence of bleeding in the adjacent lung field of Fine-Needle Aspiration is lower than that of Core-Needle Biopsy.