Effect Of Psychotic Symptoms On Self-referential Processing Of Bipolar Disorder

Objectives By analyzing the event-related potentials of self-reference processing tasks to investigated the behavioral and neuroelectrophysiological characteristics of self-reference processing in patients with bipolar disorder accompanied by psychotic symptoms and bipolar disorder patients without psychotic symptoms,and normal control groups.Methods Experiment 1:32 patients with bipolar disorder and 64 control groups were recruited to finish the self-reference processing paradigm to test their recognition scores under three different conditions.Experiment 2: Combining event-related potential(ERP)technology with self-reference memory(SRM)tasks to evaluate the selfreference process of 23 bipolar patients and 27 normal control groups.Results Experiment 1: In the recognition stage,the difference between the correct recognition scores of the bipolar disorder patient group with psychotic symptoms,the bipolar disorder patient group without psychotic symptoms and the normal group(all P<0.01).At the coding stage,there was no significant difference between the responses of the three groups of subjects under the self-reference conditions(P>0.05),but significantly higher than others’ reference conditions and font reference conditions(all P<0.01).Experiment 2: All subjects showed a reliable self-reference effect,but the patients with bipolar disorder had poor cognitive scores for self and others’ reference conditions.In the bipolar disorder patient group,the voltages of N1 and P2 under selfreference and others’ reference conditions were both small,but the positive slow-wave voltage was large.Compared with the normal control group,patients with bipolar disorder induced greater amplitudes of P3 under self-reference conditions.In addition,bipolar disorder patients without psychotic symptoms have a relatively normal self-reference effect,but the self-reference effect of patients with bipolar disorder accompanied by psychotic symptoms disappears;slow-wave positive amplitude of patients with bipolar disorder without psychotic symptoms It is larger than the normal control group,and the patients with bipolar disorder accompanied by psychotic symptoms have no difference in the positive wave amplitude of the normal control group(P>0.05).Conclusions In summary,compared with the normal control group,bipolar patients have impaired self-reference processing.Patients with bipolar disorder accompanied by psychotic symptoms are more significantly impaired in self-reference processing than those with bipolar disorder patients without psychotic symptom.Figure18;Table4;Reference 137...