| Objectives By observing the effect of Liqi Ziyin Huatan Decoction on the maximum diameter of thyroid nodules,the number of nodules and TCM clinical syndromes,the clinical efficacy of Liqi Ziyin Huatan Decoction was evaluated,so as to provide clinical basis for the treatment of benign thyroid nodules with qi stagnation yin deficiency phlegm obstruction.Methods A total of 80 patients who visited the thyroid outpatient department of Cangzhou hospital of integrated TCM-WM·Hebei from January 2019 to October 2019 and met the inclusion criteria for benign thyroid nodules with qi stagnation yin deficiency phlegm obstruction were selected.The patients voluntarily signed an informed consent and were randomly divided into the experimental group(40 cases)and the control group(40 cases)according to the random number table method.The experimental group was given Liqi Ziyin Huatan Decoction(granules),150 ml warm water,one dose daily,and divided before breakfast and dinner.Control group was given 0.7g prunella spike capsule orally 2/ day.After taking the drug for 3 months,the maximum thyroid nodule diameter,nodule number,TCM syndrome score,thyroid function,liver function and renal function of subjects in the two groups were observed before and after treatment.SPSS22.0 statistical software was used for data statistical analysis,and P<0.05 was considered as statistically significant.Results 1.Comparison of general data: A total of 35 cases(3 cases of shedding and 2 cases of elimination)were completed in the experimental group,and a total of 38 cases(0 cases of shedding and 2 cases of elimination)were completed in the control group.Data of the remaining 73 subjects were statistically analyzed: there was no statistical significance in gender,age,disease course and number of nodules(single or multiple)between the two groups before treatment(P<0.05).2.Comparison of thyroid ultrasound: 1)Maximum nodule diameter: the maximum nodule diameter of the subjects in both groups decreased after treatment compared with before treatment,and the differences were statistically significant(P<0.05).Nodule shrinkage was more significant in the experimental group after treatment compared with the control group,and the difference was statistically significant(P<0.05).2)Number of nodules: After treatment,the number of nodules in the experimental group and the control group did not change significantly compared with that before treatment,and the difference was not statistically significant(P>0.05).3.Efficacy analysis: 1)efficacy of maximum nodule diameter: The experimental group cured 0 cases,obvious effect 7 cases,effective 18 cases,ineffective 10 cases,the total effective rate of 71.43%.In the control group,0 cases were cured,4 cases were effective,10 cases were effective,and 24 cases were ineffective,with a total effective rate of 36.84%.By rank-sum test,the difference was statistically significant(P<0.05).2)TCM syndrome effect: In the experimental group,0 cases were cured,6 cases showed obvious effects,22 cases were effective,and 7 cases were ineffective,with a total effective rate of 80.00%.In the control group,0 cases were cured,0 cases showed significant effect,13 cases were effective,25 cases were ineffective,and the total effective rate was 34.21%.By rank-sum test,the difference was statistically significant(P<0.05).3)Total score of TCM syndrome: The TCM syndrome scores of the two groups decreased after treatment compared with before treatment,and the differences were statistically significant(P<0.05).Compared with the control group,the total score of TCM syndrome in the experimental group decreased significantly after treatment,and the difference was statistically significant(P<0.05).4)Single TCM syndrome score: In the experimental group,the score of each single TCM syndrome decreased significantly after treatment,except that the score of eye dryness was not decreased significantly.The difference was statistically significant(P<0.05).After treatment,the scores of the subjects in the control group decreased significantly in neck swelling,pharyngeal foreign body sensation,cervical fullness,emotional paralysis,and dry eye syndrome,and the difference was statistically significant(P<0.05).The residual syndrome integral did not change significantly.Comparing the two groups after treatment,the results showed that in the experimental group,except for the score of syndrome of dry eye and astringency,the score of other single TCM syndrome decreased significantly compared with the control group,and the difference was statistically significant(P<0.05).4.Biochemical safety index: The thyroid function(FT3,FT4,TSH),liver function(ALT,AST),renal function(Cr,Urea)of the two groups were all in the normal range before and after treatment,and the differences were not statistically significant(P>0.05).Conclusions 1 Liqi Ziyin Huayan Decoction can effectively reduce the diameter of the largest thyroid nodule in patients with benign thyroid nodule(qi stagnation yin deficiency phlegm obstruction type).2 Liqi Ziyin Huatan Decoction has no effcct on the number of thyroid nodules in patients with benign thyroid nodule(qi stagnation yin deficiency phlegm obstruction type).3 Liqi Ziyin Huatan Decoction ?can improve the TCM clinical syndrome of patients with benign thyroid nodule(qi stagnation yin deficiency phlegm obstruction type).Figure0;Table14;Reference 131... |
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