Study On DBS Tissue Activation Volume Estimation And Neural Regulation Visualization

Parkinson's disease(PD)is a progressive degenerative disease of the central nervous system.For patients with severe PD,deep brain stimulation(DBS)is more appropriate than traditional destructive surgery.Although DBS has achieved certain success in the treatment of dyskinesia,the lack of intuitive guidance by doctors during postoperative procedure adjustment is prone to side effects.In this paper,based on the three-dimensional reconstruction of key anatomical structures and implanted electrodes,the study of DBS tissue volume activated(VTA)estimation and visualization is carried out.First,the Pacer algorithm is used to extract and reconstruct DBS implanted electrodes from post-operative CT images;then,the atlas thalamic nucleus(STN)segmentation and three-dimensional reconstruction are performed by the map registration method,which is mainly The global and local registration of the atlas constructed with the 7T MRI image and the patient's T2-weighted MR image is achieved;then,based on the diffusion tensor imaging(Diffusion Tensor Imaging,DTI),a probabilistic tracking method is used to realize the STN adjacent corticospinal system(corticospinal system,CST);finally,based on the reconstruction of electrodes,STN and CST,the anisotropic conductivity of brain tissue is calculated by DTI to realize the VTA estimation of two theoretical models,simulating DBS implanted electrodes under high-frequency electrode stimulation The distribution of the electric field in the brain integrates the above information in the 3D Slicer platform to realize the visualization of individual nerve regulation.This article uses clinical data to retrospectively analyze the neuromodulation visualization.When clinical symptoms of muscle twitching occur,the VTA estimation results in DBS overlap with CST,and the neuromodulation visualization results are consistent with the clinical manifestations.This paper quantitatively estimates the volume of tissue directly affected by electrical stimulation in DBS,and helps clinicians to intuitively understand the prediction of VTA under high-frequency electrical stimulation of implanted electrodes during the process of adjusting parameters by visual means to avoid side effects.