Analysis Of Clinical Characteristics Of Parietal Cell Antibody Positive Patients

Objective: Parietal cell antibody（PCA）is an important member of the autoantibody family.It is a disorder of the body’s immune system.B lymphocytes react against the H⁺/ K⁺-ATPase on the surface of the gastric wall cells and secrete a class of immunoglobulins.Once produced,the immune response with the corresponding target antigen damages its structure and function,reducing its functions such as secretion of H⁺and internal factors.Fe³⁺ in H⁺-reduced foods cannot be reduced to Fe²⁺and iron deficiency anemia occurs.Insufficient endogenous factor secretion of vitamin B12（VB12）,a malabsorption disorder,VB12 is an important co-factor for methyl transfer in the body,and malabsorption causes blockage of homocysteine methylation and accumulates in the body,causing H-type hypertension.Under the continuous action of PCA,the destruction of gastric parietal cells increased,and even atrophic gastritis such as atrophic gastritis and other organic lesions occurred.PCA is the originator of many chronic diseases,and early detection is of great significance.The purpose of this study is to identify the clinical characteristics of the large sample PCA positive population,facilitate clinical recognition and early detection,and then take effective measures to control the disease progression,so as to realize the early prevention and treatment of a variety of chronic diseases.Method: Collected and sorted out the medical records of PCA testing in the baoding first central hospital from October 2017 to September 2019,conducted retrospective analysis and cross-sectional investigation on the clinical characteristics of PCA positive patients,and conducted comparative analysis with PCA negative patients.Count data statistical analysis using Χ² inspection;PCA was detected by indirect immunofluorescence.Results: 1.In the past two years,a total of 3153 cases of PCA were detected in the laboratory of our hospital,of which 1121 cases were positive,with a positive detection rate of 35.55%（1121/3153）.2.The incidence of decreased red blood cells and increased HCY in laboratory tests in 1121 patients with PCA was higher,accounting for 37.91%（425/1121）and 69.05%（774/1121）,respectively,which were significantly higher than those in the PCA negative group,with statistically significant differences.3.The clinical characteristics investigation of 1121 PCA positive patients showed that the incidence of gastroesophageal reflux,hypertension,coronary heart disease and cerebrovascular disease was higher,accounting for 65.39%（733/1121）,81.53%（914/1121）,15.25%（171/1121）and 31.49%（353/1121）,respectively,which were significantly higher than those of PCA negative group,with statistically significant differences.4.Among the 3153 patients with PCA,1517 were examined by gastroscopy,among which 465 were positive and 1052 were negative.In 465 positive cases,156 cases were diagnosed with atrophic gastritis under the microscope,accounting for 33.55%（156/465）.Among the patients with negative 1052,95 cases were diagnosed with atrophic gastritis,accounting for 9.03%（95/1052）.Among the patients with negative,the diagnosis rate of atrophic gastritis was significantly lower than that of the patients with positive,X²=140.38,P<0.01.Conclusion: PCA is the causative factor of many diseases,and the positive population has a higher incidence of anemia,atrophic gastritis,H-type hypertension and other diseases.For high-risk groups,early detection of PCA and effective measures to control the progression of the disease,the early stage of various diseases preventing and promoting the health of all people is of great significance.