Research On The Relationship Between TAFI And The Incidence,severity And Prognosis Of Acute Cerebral Infarction

Objectives:Thrombin-activable fibrinolysis inhibitor?TAFI?is a kind of plasminogen that can be activated by thrombin,thrombomodulin,plasmin and other substances,which plays a regulatory role in coagulation system,fibrinolytic system and inflammatory response,so TAFI and its gene polymorphism have become markers of the severity,progression and prognosis of many diseases.The purpose of this research was to explore the risk factors of acute cerebral infarction?ACI?,the relationship between TAFI and the severity of ACI,and the effect of the difference of TAFI level within 72 hours and 7 days after,so as to provide a basis for etiological study,early diagnosis and treatment and follow-up prevention and treatment of ACI.Methods:In this study,a case-control study was used to collect the general clinical data,laboratory data and clinical scores of 192 patients hospitalized in the Department of Neurology of CMU Hospital from April 2018 to April 2019.The plasma TAFI levels of138 patients with ACI were compared with 54 patients without ACI by enzyme-linked immunosorbent assay??ELISA??,and the data were summarized and statistically analyzed.Results:1.The variables with significant differences?such as diabetes history,glycosylated hemoglobin,cystatin C,TAFI?were assigned by univariate analysis between the case group and the control group,and further binary Logistic regression analysis showed that cystatin C and TAFI were independent risk factors for ACI,and the level of TAFI in the case group was higher than that in the control group.2.Mild neurological impairment group?0?NIHSS score?3?TAFI=23.39±3.59,moderate neurological injury group?4?NIHSS score?15?TAFI=26.67±3.99,severe neurological injury group?NIHSS score>15?TAFI=31.07±2.34,the result of one-way ANOVA showed that there was a difference in TAFI among the three groups,and the higher the NHISS score was,the higher the TAFI value was.3.?TAFI=TAFI₁-TAFI₇,good prognosis group?0?mRS score?2??TAFI=4.880?5.625,9.638?,poor prognosis group?3?mRS?6??TAFI=4.880?0.42,8.28?.The rank sum test of independent samples of the two groups showed that the TAFI difference of different prognosis group was different,and the Mann-Whitney U test showed that the TAFI difference distribution of the two groups with different prognosis was significant.Conclusion:1.TAFI may be an independent risk factor for ACI,and the level of plasma TAFI in patients with ACI is significantly higher than that in the control group.2.The higher the NHISS score,the higher the TAFI value,and the high level of TAFI indicates that the condition of patients with acute ischemia stroke is serious.3.?TAFI was obtained by subtracting the value of TAFI on the first and seventh day of admission in the case group.The greater the difference of TAFI,the better the prognosis of patients with acute ischemia stroke.