Experimental Study On Biocompatibility Of Intraocular Lens With Different Surface Modelings And Designs

Objective: To compare the biocompatibility of intraocular lens(IOL)implantation in rabbits with different surface modelings and designs.Methods: Ten New Zealand white rabbits(20 eyes)were treated with phacoemulsification combined with intraocular lens implantation.Each rabbit was randomly assigned a different intraocular lens to left or right eye.Group A received HOYA Vivinex XY1 IOL,which featured by ultraviolet/ozone(UV/O3)back surface modeling and textured-rough haptic surface,while group B received AMO Tecnis PCB00 IOL featured by polyethylene glycol(PEG)full surface modeling and smooth haptic surface.Anterior chamber flare score,posterior capsule opacification score and IOL rotation angle were observed at 1days,7days,14 days,28days after surgery.After 28 days of surgery,the rabbit eyes were removed and sectionized by paraffin embedding,and the hematoxylin-eosin staining method was used to observe the proliferation and migration of lens epithelial cells on posterior capsule.Result: 1.Anterior chamber flare score:The mean anterior chamber flare score of group A was greater than that of group B at 1days and 7days after surgery,and the difference was statistically significant(P<0.05).The anterior chamber flare of group A and group B was the most obvious at 7days after surgery,and gradually decreased with the time,and basically disappeared at 28 days after surgery.2.Posterior capsule opacification score: The mean posterior capsule opacification score of group A was lower than that of group B at 7days,14 days,28days postoperatively,and the difference was statistically significant(P<0.05).Posterior capsular opacification began to appear in group A at 14 days after surgery,and in group B at 7days after surgery,which gradually increased with time.3.IOL rotation angle: At 1days,7days,14 days,28days after surgery the average intraocular lens rotation angle of group A was smaller than that of group B,and the difference was statistically significant(P<0.05).In group A,there was no significant change in the average intraocular lens rotation angle at 1days,7days,14 days,28days after surgery.In group B,the average intraocular lens rotation angle increased with time at 1days,7days,14 days after surgery,while the average intraocular lens rotation angle tended to be stable on 14 days and 28 days after surgery.4.The hematocellin-eosin staining of the rabbit eyes at 28 days after the surgery showed that only single or clustered lens epithelial cells were found on the posterior capsule surface of group A,and the deposition of extracellular matrix was not obvious.In group B,the posterior capsule surface showed dense arrangement of lens epithelial cells in single or double layers.The extracellular matrix deposition was obvious and the posterior capsule was significantly thickened.Conclusion: 1.The intraocular lens,which full surface modeling with PEG can reject the adhesion of inflammatory cells and reduce the inflammatory reaction after surgery,and the uveal biocompatibility is good.2.The intraocular lens,which back surface modeling with UV/O3 can increase the surface adhesion,inhibit the proliferation and migration of lens epithelial cells,delay and reduce the occurrence of posterior capsule opacification,and the capsule biocompatibility is good.3.The intraocular lens with textured-rough haptic surface can increase the friction between the intraocular lens haptic and capsule,which is conducive to maintaining good rotational stability of the intraocular lens in the capsule.