Correlation Between Serum Lipoprotein Associated Phospholipase A2 Level And Coronary Heart Disease

Objective: To explore the correlation between serum lipoprotein associated phospholipase A2(Lp-PLA2)level and coronary heart disease.Methods:362 patients who were admitted to the Department of Cardiology of Yongzhou Central Hospital from March 2017 to October 2017,Suspected chest pain,coronary angiography(CAG)was performed,and the level of serum Lp-PLA2 was measured at the same time,and conformed to the standard of admission.All patients were examined with blood bioch-emistry(liver and kidney function,fasting blood glucose,blood lipid,thyroid function,etc).In this experiment,four groups were used:(1)according to the expert suggestion of lipoprotein related phospholipase A2 clinical application,the level of Serum lp-PLA2 > 175ng/ml as high level group,?175ng/ml as normal group[ 1-2 ].(2)According to the clinical types of coronary heart disease,the patients were divided into four subgroups: normal group,stable angina group,unstable angina pectoris group,acute myocardial infarction group.(3)According to the results of coronary angiography,the patients were divided into five groups: normal group,atherosclerosis group,single vessel lesion group,double vessel lesion group and three vessel lesion group.(4)According to the results of coronary angiography,Gensini score was used and divided into four groups: mild lesion group(0~<20 points)?moderate lesion group(20~ < 40 points)?severe lesion group,the scores of(40 ~ <60 points)and extremely severe lesion group(?60 points).The level of Serum Lp-PLA2 was measured by ELISA method.Comparison of Lp-PLA2 levels between different clinical types of coronary heart disease and normal group;The levels of Lp-PLA2 were compared in different coronary lesions group and normal group;Compare the Lp-PLA2 levels between each Gensini integral group and between normal groups.SPSS20.0 statistical software is used to analyze and process data.The correlation between the level of Lp-PLA2 and Gensini integral was studied by Spearman rank correlation analysis.The risk factors of coronary heart disease were analyzed by Logistic stepwise regression analysis.The difference was statistically significant(P < 0.05).Results:(1)The incidence of coronary heart disease in high Lp-PLA2 group was higher than that in normal group;(2)The levels of Lp-PLA2 in each clinical type of coronary heart disease group and normal group: the clinical type of coronary heart disease group > the normal group,The difference was statistically significant(P<0.05),the stable angina group<unstable angina pectoris group<acute myocardial infarction group,and every comparison between the two,the difference was statistically significant(P<0.05);(3)The levels of Lp-PLA2 in each coronary artery lesion group and normal group: each coronary artery lesion group > normal group,the difference was statistically significant(P < 0.05),in which the atherosclerosis group < single vessel lesion group < double vessel lesion group < three vessel lesion group,and each of the two groups was compared.The difference was statistically significant(P < 0.05);(4)Lp-PLA2 level of each Gensini integral group and normal group: normal group < each Gensini integral group,the difference was statistically significant(P < 0.05).the scores of(0 ~ < 20)group < the scores of(20~ < 40)group < the scores of(40 ~ < 60)group < the scores of(?60)group,And every comparison between the two,the difference was statistically significant(P < 0.05);(5)There was a positive correlation between serum Lp-PLA2 level and gensini score,and the correlation coefficient was r = 0.861(P < 0.05),that is,serum Lp-PLA2 level was positively correlated with the severity of coronary artery disease.(6)Age,sex,smoking,high blood pressure,dyslipidemia,obesity,diabetes,hyperhomocysteinemia,and high Lp-PLA2 levels are risk factors for coronary heart disease.Conclusions:(1)The high level of Lp-PLA2 is a risk factor for coronary heart disease;(2)The level of serum Lp-PLA2 is closely related to the clinical type of coronary heart disease;(3)The level of serum Lp-PLA2 is positively correlated with the severity of coronary artery disease.