Correlation Between The Levels Of Plasma Lipoxin A4,Resolvin D1,Protectin D1 And The Severity And Clinical Prognosis Of Coronary Heart Disease

Objective To investigate the correlation between plasma levels of lipoxin A4(LXA4),resolvin D1(Rv D1),protectin D1(PD1)and the severity and clinical prognosis of coronary heart disease(CHD).Methods According to the history and clinical examination,150 patients with CHD were selected and divided into stable angina pectoris(SAP)group,unstable angina pectoris(UAP)group and acute myocardial infarction(AMI)group.Meanwhile,according to the number of coronary artery lesions,the 150 patients were divided into single-branch,double-branch and three-branch lesion groups,moreover,the Gensini score was performed.Twenty-six healthy people were selected as the control group.According to whether major adverse cardiovascular events(MACE)occurred during the follow-up,patients with CHD were divided into poor prognosis group and good prognosis group.The levels of plasma LXA4,Rv D1 and PD1 were detected,and their correlations with the clinical type of CHD,number of coronary artery lesions,Gensini score and incidence of MACE were analyzed.Results(1)Compared with control group,the levels of plasma LXA4,Rv D1 and PD1 were significantly lower in SAP group,UAP group and AMI group(P<0.05).Compared with SAP group,the level of plasma LXA4 in UAP group and the levels of plasma LXA4,Rv D1 and PD1 in AMI group were significantly lower(P <0.05),while the levels of plasma Rv D1 and PD1 were no significant difference between SAP group and UAP group(P >0.05).Compared with UAP group,the levels of plasma LXA4 in AMI group were significantly lower(P<0.05),while the levels of plasma Rv D1 and PD1 were no significant difference between UAP group and AMI group(P>0.05).(2)The levels of plama LXA4 and Rv D1 in the single-branch lesion group were significantly lower than those in control group(P<0.05),while the level of plasma PD1 was no significant difference between them(P<0.05).The level of plasma LXA4 in the double-branch lesion group was significantly lower than that in control group(P<0.05),the levels of plasma Rv D1 and PD1 were no significant difference between them(P<0.05).The levels of plasma Rv D1 and PD1 in the three-branch lesion group were significantly lower than those in control group(P<0.05),while the level of plasma LXA4 was no significant difference between them(P>0.05).The plasma levels of plasma LXA4,Rv D1 and PD1 were no significant difference between single-branch lesion group,double-branch lesion group and three-branch lesion group(P>0.05).(3)The levels of plasma LXA4,Rv D1 and PD1 were negatively related to C-reactive protein and interleukin-6(IL-6)(?=-0.263,-0.367;-0.247,-0.229;-0.251,-0.302,P<0.01),but positively related to IL-10(?= 0.258,0.245,0.211,P <0.01).The levels of plasma Rv D1 and PD1 were negatively related to Gensini score(?=-0.227,-0.229,P<0.01),however,there was no significant correlation between LXA4 and Gensini score(?=-0.100,P>0.05).Stepwise multiple linear regression showed that the levels of plasma LXA4,PD1 and Rv D1 had little effect on Gensini score.Stepwise multiple logistic regression showed that plasma IL-10 and PD1 were the protective factors for CHD.(4)Compared with poor prognosis group,the level of plasma PD1 was significantly higher at 3 months of follow-up in the good prognosis group(P<0.01).Conclusion The level of plasma PD1 can effectively judge the clinical severity of CHD patients,which is a protective factor of CHD and has predictive value for short-term prognosis of CHD patients,while the values of plasma LXA4 and Rv D1 are weak.