Study On The Correlation Between Recurrent Respiratory Tract Infection And The Level Of Vitamin A And Vitamin E In Children

Respiratory infection is the most common disease in children.Repeated respiratory tract infection refers to the frequent occurrence of upper and lower respiratory tract infection within one year,which is beyond the normal range.In the process of children's growth and development,repeated respiratory tract infection has adverse effects on children's physical and mental health and children's growth and development.The causes of repeated respiratory tract infection in children are various.Past studies and treatments are always based on the perspective of etiology,ignoring the deficiency of vitamin A and vitamin E would also lead to immune imbalance and repeated respiratory tract infection in children.Therefore,the study on children's repeated respiratory tract infection and vitamin A and E levels in serum can provide theoretical basis for children's health care and clinical treatment of repeated respiratory tract infection.Objective:Study on the correlation between recurrent respiratory tract infection and vitamin A and E levels in children's serum.Methods:From November 2017 to November 2018,134 health children and 116 children with repeated respiratory tract infection in the department of pediatric medicine of affiliated hospital of Chengde medical college are selected as the experimental sample.According to the age,they are divided into 1-12 months old group,1-3 years old group and 3-14 years old group.Venous blood is extracted and vitamin A and E levels in their serum are quantitatively tested by HPLC.Statistical methods such as ANOVA,one-way ANOVA,correlation analysis and ?2 test are used to analyze items as follow:1.Relationship between repeated respiratory tract infection and vitamin A and E levels in children's serum.2.Comparison of vitamin levels among different age groups with repeated respiratory tract infection.Results:1.Vitamin A levels in the serum of the group with repeated respiratory tract infection(0.26±0.09mg/L)are significantly lower than that of the physical health group(0.34±0.08mg/L),with statistically significant difference(P < 0.05).2.Vitamin A levels(0.22±0.06mg/L,0.29±0.06mg/L,0.29±0.13mg/L)in all age groups(1-12 months,1-3 years,3-14 years)are lower than those in the same age of health groups(0.28±0.06,0.37±0.06,0.37±0.08),with statistically significant differences(P < 0.05).3.Vitamin A levels in different age groups are comparable among patients with repeated respiratory tract infection(P < 0.05).Differences between the 1-12 months old group and the 1-3 years old group and differences between 1-12 months old group and 3-14 years old group are significant(P < 0.05),while the differences between the 1-3 years group and the 3-14 years group are not significant,without statistically significant differences(P < 0.05)(P > 0.05).4.There is no significant difference in vitamin E levels in serum between experimental groups(8.71±3.42mg/L)and control groups(9.21±2.42mg/L),without statistically significant differences(P < 0.05).5.There is no significant difference in vitamin E levels in the serum(9.68±3.78mg/L,8.61±2.78mg/L,7.06±2.82mg/L)between the experimental groups and the control groups(10.21±2.67mg/L,9.03±2.22mg/L,8.42±2.05mg/L),without statistically significant differences(P < 0.05).Conclusion:1.Compared with healthy children,the serum vitamin A level of children with recurrent respiratory tract infection is lower,suggesting that vitamin A may be related to the occurrence and development of children with recurrent respiratory tract infection.2.Compared with children over one year old,the vitamin A level in the 1-12 months old is lower and there is no difference between children and children above one year old.and there is no difference in serum vitamin A between children aged 1-3 years and children aged 3-14 years,which is related to the nutritional structure and vitamin A intake in infancy.3.There is no significant correlation between the vitamin E level in serum and repeated respiratory tract infection in Chengde District,and the level of vitamin E is stable in Chengde District.