Correlation Between Obesity And Medication Overuse Headache

Objective:The purpose of this study was to analysize the relationship between obesity and medication overuse headache by determining height,weight,waist circumference and lipid levels of patients.Methods:A total of 40 patients with medication overuse headache,from October 2018 to May 2019,who were admitted to the affiliated hospital of chengde medical college.Forty patients without headache who underwent physical examination in our hospital during the same period were selected as the normal control group(referred to as the control group).According to the diagnostic criteria of medication overuse headache and excluding other secondary headache,the basic demographic characteristics,headache duration and frequency,family history and other conditions were recorded,and height,weight and waist circumference were measured.Serum lipids were measured on the Beckman bioanalyzer.BMI and WC values of the MOH group and the healthy control group were compared.MOH patients were divided into total body obesity group(TBO)and non-tbo group according to BMI,and were divided into abdominal obesity group(abd-o)and non-abd-o group according to WC,to compare the effects of TBO group and non-tbo group,abd-o group and non-abd-o group on MOH.The effects of total cholesterol,triglycerides,LDL cholesterol and HDL cholesterol on MOH were analyzed in MOH group and healthy control group,TBO group and non-tbo group,abd-o group and non-abd-o group.Results:1 Comparison between the MOH group and the control group1.1 There were no statistically significant differences in gender,age and blood lipid between the MOH group and the control group(p>0.05).WC andBMI was of statistical significance(P<0.05).1.2 Binary Logistic regression analysis showed that BMI(OR 3.138p<0.05)and HDL(OR 3.874 P<0.05)may be risk factors for MOH.2 Comparison between TBO group and non-tbo group2.1 Compared with the non-TBO group,there was no statistical significance in age,gender,occupation,education level,course of disease,drug type in the TBO group(p>0.05),but there was statistical significance in VAS score(P<0.05).2.2 TG and LDL-C levels in TBO group and non-TBO group were significantly different(P<0.05).3 Comparison between ABd-O group and non-ABd-O group3.1 There was no significant difference in age,occupation,education level and drug type between ABd-O group and non-ABd-O group(P>0.05).There were significant differences in gender,course of disease,VAS score(P<0.05).3.2 Comparison of serum lipid levels between ABd-O group and non-ABd-O group showed no statistical significance in TC,TG and LDL-C(P> 0.05).HDL-C was statistically significant(P<0.05).4 Spearman correlation analysis showed that VAS score was positively correlated with BMI(r=0.328,P=0.039),TC(r=0.360,P=0.022),TG(r=0.412,P=0.008)and LDL-C(r=0.494,P=0.001).Conclusion:1 WC and BMI is correlated with the occurrence of MOH,and is correlated with the severity of MOH headache.2 HDL-C and obesity may be a risk factor for headache in MOH patients.3 Both TBO and ABd-O may be the reason for the aggravation of headache in MOH patients.Both dyslipidemia and BMI can lead to MOH and increase the severity of the headache.