Effectiveness Of Caprini Thrombosis Risk Assessment Model For Predicting The Risk Of Deep Vein Thrombosis In Patients With Lung Cancer

Objective:To explore the effectiveness of Caprini thrombosis risk assessment model in predicting the risk of deep vein thrombosis in patients with lung cancer,and to provide basis for clinical workers to develop thrombosis risk assessment scale in line with China's national conditions.Methods:Using case-control study,the use of chengde city central hospital medical record management section were collected from January 2014 to December 2018 in chengde city central hospital,a total of 300 patients with pulmonary malignant tumor,including 100 patients of lung cancer combined VTE as case group(blood clots),according to the proportion of 1:2 choice at the same time to the hospital of VTE in patients with lung cancer,200 cases as control group,collect,sort out the general clinical data of two groups of patients.According to Caprini thrombotic risk assessment scale,thrombotic risk score and risk grading were performed for the two groups of patients,and the general clinical data,scoring status and risk grading composition of the two groups were compared.A binary Logistic regression model was used to analyze the risk factors in Caprini scale,to obtain the risk factors of lung cancer complicated with VTE,and to analyze the relationship between different risk grades and the risk of VTE in lung cancer patients.Results:The comparison of the general clinical data between the two groups showed that the smoking rate(55.0%),the elevated rate of d-dimer(67.0%)and the chemotherapy rate(89.0%)in the thrombus group were significantly higher than those in the control group(42.5%),the elevated rate of d-dimer(15.5%)and the chemotherapy rate(76.5%),with statistically significant differences(P < 0.005).The difference in tumor staging ratio and surgical rate between the other two groups was statistically significant(P < 0.005).Caprini risk score(6.98±2.188)in the thrombus group was significantly higher than that in the control group(2.60 ± 1.620),with statistically significant difference(P < 0.001).In the thrombus group,the proportion of patients with high risk by Caprini thrombus risk assessment scale was 98.0%,significantly higher than the control group(41.0%),and the difference was statistically significant(P < 0.001).The Caprini risk factors in the risk assessment scale of Logistic regression analysis: serious lung diseases,including pneumonia(one month),medical patients lying in bed,lower limb edema,central venous catheter,malignant tumor,history of deep vein thrombosis or pulmonary embolism six Caprini blood clots in the risk assessment scale factor is a major risk factor for lung cancer merger VTE.Further analysis showed that d-dimer,medical patients in bed,lower limb edema,central venous catheterization,previous malignant tumor,history of deep vein thrombosis or pulmonary embolism were independent risk factors for lung cancer with VTE.Patients with the risk grade of extremely high risk were at high risk of developing VTE of lung cancer,and the risk of developing VTE in patients with extremely high risk of lung cancer was 36.573 times higher than those with low risk.Conclusion:Caprini thrombotic risk assessment model can well assess the risk of VTE in patients with lung cancer,providing assistance for the formulation of appropriate thrombotic risk assessment scale for patients with malignant tumors,especially lung cancer in China.