Correlation Between Cerebral Microbleed And Cognitive Impairment

Objective:The purpose of this study is to studythe correlation between cerebral microbleed(CMB)and cognitive impairmentMethods:Retrospective analysis system in September 2018 to October 2019 in the fourth hospital affiliated to China medical university neurology hospital Susceptibility Weighted Imaging(SWI),According to the results of MOCA score,they were devided into normal cognitive function group(MOCA>26)and abnormal cognitive function group(MOCA<26).The risk factors were compared between the two groups,;According to whether there is cerebral microbleed,the patients were divided into CMB positive group and CMB negative group.And to explore the relationship between the location?number of CMB and cognitive function.Measurement data were t tested,counting data were tested with x 2 test,rank data were tested with mann-whitney rank sum test,and binary Logistic regression analysis was performed to furtheranalyze the risk factors of CMB,P<0.05 representing that the analysis results were statistically significant.Results:1.Risk factor distribution of the patients:140 patients,were divided into two groups according to cognitive function:108 patients in normal cognitive group and 32 patients in abnormal cognitive function group.Comparison of general clinical data between the two groups:comparison of age,smoking,gender,hypertension,diabetes,hypercholesterolemia,low density lipoprotein,triglyceride,high homocysteine uric acid,etc.The differences were not statistically significant,but leukoaraiosis(P=0,000),CMB number(P=0,000)and positive(P=0,000)were statistical significance between the two groups.According to the group of microbleeds,107 patients in CMB negative and 33 in CMB positive group were compared in clinical data.it was found that hypertension(P=0.021),diabetes,(P=0.029)uric acid(P=0.009)and Hcy(P=0.004)in CMB positive group were significantly increased,and the difference was s statistically significant2.Multiple Logistic regression analysis:the significant risk factors for cognitive impairment:leukoaraiosis,the number and positive of CMB were included in the logistic model for regression analysis.Found thatleukoaraiosis(OR=2.55,P=0.000),number of CMB(OR=1.37,P=0.031),positive of CMB(OR=7.25,P=0.048)were the risk factors of cognitive impairment.The significant risk factors for CMB:hypertension,diabetes,uric acid and Hcy were included in the logistic regression model for regression analysis.it was found that hypertension(OR=2.44,P=0.046),diabetes(OR=2.53,P=0.041),uric acid(OR=1.01,P=0.028)were the risk factors for CMB positive3.The relationship between the location and number of CMB and MOCA score:there was a significant correlation between the brain lobe CMB and the total score of MOCA(P<0.05).At the same time,CMB in the brain lobe was significantly correlated with the scores of visual space and executive function,naming,attention,delayed memory and orientation(P<0.05),while CMB in the deep brain was significantly correlated with the scores of naming,attention and orientation(P<0.05),and CMB under the curtain was significantly correlated with the sores of naming and delayed memory(P<0.05).The more number of CMB,the more serious damage to cognitive functionConclusion:1.Leukoaraiosis and CMB positive are independent risk factors for cognitive impairment.2.The independent risk factors of CMB are hypertension,diabetes and uric acid3.Different parts of CMB have different areas of cognitive impairment.CMB in the lobar area has the most significant effect on cognitive function.The more number of CMB,the higher positive rate of CMB,the more serious damage to cognitive function.