Difference Analysis Of Endocrine And Metabolic Indexes Between Obese Polycystic Ovary Syndrome Patients And Obese Individuals

Objective:To compare the differences of endocrine and metabolic indexes between obese polycystic ovary syndrome（PCOS）and obese non PCOS patients,in order to explore the related factors that affect the pathogenesis and progress of PCOS.Methods:In between April 2018 and January 2019 in our hospital outpatient clinic of 43cases of obese patients with PCOS,at the same time from 31 cases except BMI matching and outpatient medical obese PCOS and 16 body mass index in 18.5-24 kg/m2 healthy volunteer blood glucose,insulin,blood lipid,liver function,renal function,sex hormone and endocrine metabolism related index for testing.Result:（1）There was no statistically significant difference in height,body mass,BMI,waist circumference,waist-to-hip ratio,fat percentage,visceral fat area,muscle content and fat content between the obese PCOS group and the obese non-PCOS group（P>0.05）.（2）In the obese non-PCOS group,BG 0min,BG 60min,BG 120min,INS 0min,INS 60min,INS 120min,INS 180min and HOMA-IR were all higher than the normal control group,while SHBG were lower than the normal control group（P<0.05）.（3）In the obese PCOS group,the AMH,AST,GGT,UA,TC,LDL,LDH5,INS 0min,INS 120min,HOMA-IR,LH,LH/FSH,T,and FAI values?were higher than in the obese non-PCOS group.FT4,E₂ and Prog were lower than obese non-PCOS group（P<0.05）,and other endocrine indexes were not statistically different.（4）In obsess sample,HOMA-IR was positively correlated with AST（r>0,P<0.05）.FAI was negatively correlated with FT4（r<0,P<0.05）.GGTand TC were positively correlated with FAI（r>0,P<0.05）.GGT,UA,TC,LDL were positively correlated with T（r>0,P<0.05）.（5）In obese PCOS patients,multiple stepped-regression analysis was conducted with FAI as the dependent variable and hs-CRP、AMH、HOMA-IR and LH/FSH as independent variables.The results showed that hs-CRP、AMH and HOMA-IR entered the regression equation（Y=-0.205-0.351×hs-CRP+0.353×HOMA-IR）,and R ²=0.299.The absolute value of HOMA-IR standardized partial regression coefficient（0.429）was greater than that of hs-CRP standardized partial regression coefficient（-0.368）.（6）Serum HOMA-IR was positively correlated with FAI in the obese PCOS group（P<0.05）.Conclusion:（1）The obese PCOS group did not show more accumulation of abdominal fat due to increased androgen levels than the BMI matched obese non-PCOS group.（2）Obese PCOS patients have more serious sex hormone abnormalities and glucose and lipid metabolism disorders than obese non-PCOS patients;the difference of some metabolic indexes may be related to insulin resistance and high androgens.（3）Hypersensitive c-reactive protein and HOMA-IR may be independent risk factors for hyperandrogenemia in obese patients;HOMA-IR was positively correlated with free testosterone index in obese PCOS patients.