Correlation Between Monocyte To High-Density Lipoprotein Cholesterol Ratio And Hypersensitive C-reactive Protein、BNP In Patients With Preserved Ejection Fraction Heart Failure Combined With Type 2 Diabetes Mellitus

Objective: To study the correlation between monocyte/high density lipoprotein cholesterol(MHR)and hypersensitive C-reactive protein 、 BNP in patients with preserved ejection fraction heart failure combined with type 2 diabetes mellitus.Experimental steps and methods: From January 2016 to January 2018,120 patients with preserved ejection fraction heart failure in cardiovascular medicine of our hospital were divided into two groups according to whether they were combined with diabetes: the group with preserved ejection fraction combined with type 2 diabetes mellitus and the group with preserved ejection fraction combined without type 2diabetes mellitus.Among them,59 patients in the group with preserved ejection fraction combined with diabetes mellitus and 61 patients in the group without diabetes mellitus,The basic information include age、gender、 weight and previous diseases of these 120 patients were collected.Vital signs such as blood pressure,heart rate were completed on the day of admission,Routine electrocardiographic examination,collection of relevant clinical laboratory indicators:glycosylated hemoglobin、creatinine、uric acid、monocyte、high-density lipoprotein cholesterol、MHR 、 BNP 、 hypersensitive C-reactive protein and other clinical laboratory indicators and Doppler echocardiography indicators were compared and analyzed.Results: Comparison between the two groups,The BMI(mean 23.02 ± 2.75 kg / m2 vs 20.7 ± 21.4kg / m2),Hb A1c(mean3.02±1.58vs5.79±0.64,p=0.00,p<0.05)fasting blood glucose(mean9.19±3.55mmol/lvs5.08±0.70mmol/l,p=0.00,p<0.05).hypersensitive C-reactiveprotein(mean7.02±1.58mg/lvs5.13±0.58mg/l,p=0.00,p<0.05)、MHR(mean1.30±0.57vs0.45±0.21,p<0.01)、BNP(mean1849.94±622.87pg/mlvs1066.70±506.73pg/ml,p<0.01)was significantly higher than that wihtout type 2 diabetes mellitus group.The difference is statistically significant;There was a positive correlation between MHR and BNP(r = 0.588,p< 0.01),the difference was statistically significant;There was a positive correlation between MHR and hypersensitive C-reactive protein(r= 0.451,p < 0.01),the difference was statistically significant;there was a positive correlation between MHR and Hb A1c(r = 0.262,p < 0.05),the difference was statistically significant.There was a positive correlation between hypersensitive C-reactive protein and BNP(r = 0.35,p < 0.01),the difference was statistically significant。Conclusion: There was a positive correlation between monocyte / high density lipoprotein cholesterol(MHR)and hypersensitive C-reactive protein(CRP)、BNP in patients with preserved ejection fraction heart failure combined with type 2 diabetes mellitus.