Observing OCTA To Detect The Morphological Changes Of The Response To Anti-VEGF Treatment Of PDR

Objective:Using optical coherence tomography angiography(OCTA)to analyze the graphic characters changes of PDR patients after the therapy of Lucentis intravitreal injection(IVR).Method: Collecting 20 cases(25 eyes)of PDR patients diagnosed and treated in the Department of ophthalmology of Shengjing Hospital.They were diagnosed by fluorescein fundus angiography(FFA)and digital fundus photography and give the intravitreal injection(IVR)of VEGF inhibitors,Lucentis,0.05 ml.Observing the OCTA and OCT results before and after this therapy at 1day,7day and 30 day.Analyzing best corrected visual acuity(BCVA),central macular thickness(CMT)and the OCTA in the model of 3mmx3 mm scan analyze to observe the foveal avascular zone(FAZ)area of SCP and DCP and the neovascularization vascular density with the help of Image J software.Result: The BCVA(Log Mar)was improved and there is a statistically significant.After therapy,the difference in CMT at the 7th day are most significant.After IVR of Lucentis therapy,the 7d and 30 d patients' OCTA results of neovascularization vascular density are lower which was regarded as a statistically significant result.The FAZ square has no difference as a statistically significant result,which result is P>0.05.Conclusion:(1)Using OCTA can show the distribution and flood flow of status of neovascularization in polar fundus for PDR patients who have a relatively clear refractive.The OCTA examination method can provide a reliable quantity index of PDR patients.(2)Using OCTA can observe the effect of IVR of Lucentis on the PDR patients.Lucentis can decrease the neovascularization vascular density.(3)OCTA can be an auxiliary method to diagnose and assess the treatment of PDR.