Correlation Analysis Of Serum Vitamin D And Insulin Resistance In Patients With Polycystic Ovary Syndrome

Objective:To investigate the levels of serum vitamin D and Insulin resistance(IR)in Polycystic ovary syndrome(PCOS).To analyze the correlation between vitamin D and IR,obesity,kaohsiung and other relevant clinical indicators;To analyze the influencing factors of vitamin D level in PCOS patients.Methods : A retrospective analysis was performed on 90 patients diagnosed with polycystic ovary syndrome(PCOS)in our hospital between 2017 and 2019.Collect general clinical data of 90 patients with PCOS,age,BMI,fasting insulin(FINS),fasting plasma glucose(FPG),homeostasis model assessment of insulin resistance(HOMA IR),quantitative insulin sensitivity check index(QUICKI),serum total testosterone(TT)and sex hormone binding globulin(SHBG),free testosterone index(FAI)and sex hormone and total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)as observation indexes such as the single factor analysis,Multivariate Logistic regression was used to analyze the influencing factors of serum 25(OH)D3 level in PCOS patients.Pearson correlation was used to analyze the correlation between the level of 25-(OH)D3 in PCOS patients and the related indicators of insulin resistance,as well as the above endocrine and metabolic indicators.Results:1)Vitamin D deficiency rate of 90 PCOS patients was 84%,among which57% of PCOS patients had insulin resistance.2)Grouping by 25-(OH)D3 level: differences in homa-ir,QUICKI and FI between the two groups were statistically significant(P<0.05).In addition,the differences in BMI and TT between the two groups were also statistically significant(P<0.05).The differences of 25-(OH)D3,BMI,homa-ir and QUICKI between the two groups were statistically significant(P<0.05).In addition,the differences in TT,FAI,SHBG and other sex hormone indicators between the two groups were also statistically significant(P<0.05).According to BMI level,there were statistically significant differences in 25-(OH)D3,FINS and homa-ir between the two groups(P<0.05).3)The correlation analysis results showed that serum vitamin D level was negatively correlated with homa-ir(R:-0.450),BMI(R:-0.315),FINS(R:-0.592),TT(R:-0.370),and QUICKI(R: 0.579).4)Multivariate Logistic regression analysis showed that QUICK was the influencing factor of serum 25-(OH)D3 level in PCOS patients(0 >,OR>1,P<0.05).Conclusion:Vitamin D levels were lower in PCOS patients and higher in IR patients,and the association between vitamin D and IR was independent of obesity.