| Objectives:1.Compare the levels of Vitamin E(VE)in the serum of children with bronchiolitis caused by respiratory syncytial virus(RSV)and healthy children,to investigate whether VE levels influence the incidence of bronchiolitis.2.The two groups of children with bronchiolitis were treated with different treatments,compared the clinical symptom relief time,average hospital stay,and changes in exhaled nitric oxide(FeNO)to evaluate the therapeutic effect and provide guidance for clinical therapy.Method:In this study,161 children diagnosed with bronchiolitis caused by RSV infection were randomly selected as the experimental group from June 2018 to December 2019 in pediatric department of Affiliated Hospital of Yan 'an University,and according to the random number method,80 children in the experimental group were selected as the VE treatment group,the remaining 81 patients were in the non-VE treatment group,a total of 161 children were randomly selected from the pediatric outpatient department of our hospital for physical examination during the same period as the control group,VE concentration and FeNO values of the three groups were compared at admission.Children in the non-VE treatment group were given routine treatments such as oxygen inhalation,antivirus,anti-infection and atomization according to their conditions,on the basis of the above treatment measures,the children in VE treatment group were taken orally with VE capsule for2 months,the differences of cough remission time,wheezing remission time,average hospital stay and FeNO value between the two groups were compared.Three months after discharge,the children in the two groups were re-hospitalized for bronchiolitis and FeNO value was changed.The above data were analyzed by SPSS.20.0.Result:1.There was no statistically significant difference between the experimental group and the control group in terms of age and gender(P>0.05);2.The comparison of serum VE concentration between the experimental group and the control group before treatment was statistically significant(P<0.05),that is,theserum VE concentration of the control group was higher than that of the experimental group.There was no statistically significant difference in serum VE concentration between the VE treatment group and the non-ve treatment group before treatment(P>0.05),indicating that the two groups were comparable.The concentration of serum VE in both groups increased at the time of discharge,and the level of serum VE in the VE treatment group was significantly higher than that in the non-VE treatment group at the time of admission,with statistical significance(P<0.05).The detection rate of low VE was 50.93% in the experimental group and 24.84% in the control group,which was statistically significant(P<0.05).The detection rate of VE deficiency was 7.45% in the experimental group and 2.50% in the control group.Theoretical frequency was less than5 and correction formula was adopted,showing no statistical significance(P>0.05).3.At admission,FeNO value of children in the experimental group was lower than that of the healthy control group,with statistically significant difference(P<0.05).The FeNO value of the children in the experimental group at discharge was higher than that of the healthy control group(P <0.05)).4.The cough relief time,wheezing relief time,and average hospital stay of children in the VE treatment group were significantly shorter than those in the non-VE treatment group,with statistical significance(P<0.05);There was a significant difference in the cure rate between the two groups.The cure rate of the VE treatment group was higher than that of the non-VE treatment group,with statistical significance(P<0.05);Three months later,it was rechecked that the number of cases of recurrent bronchiolitis in the VE treatment group in the experimental group was significantly lower than that in the non-VE treatment group,and the difference was significant and statistically significant(P<0.05).Conclusion:1.Serum VE levels have an effect on the incidence of bronchiolitis caused by RSV,when VE is low and lacking,it may be more likely to cause bronchiolitis.2.Adding VE orally on the basis of the conventional treatment plan can improve the curative effect and improve the cure rate.3.FeNO value of bronchiolitis in the acute phase is lower than that of healthy children,and FeNO value at discharge is higher than that at admission,suggesting that the acute phase may be inhibited by NO production,and eosinophils dominate the recovery period.4.The appropriate amount of VE supplementation for children with bronchiolitis caused by RSV infection can significantly reduce the recurrence rate within 3 months after discharge. |
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