Related Risk Factors And Prognosis Of Patients With Non-hematological Malignant Tumors Complicated With AKI

Objectives:To explore the risk factors of acute kidney injury(AKI)in patients with non-hematological malignancies;To explore the factors influencing the prognosis of patients with non-hematological malignant tumors complicated with acute kidney injury(AKI);The purpose of this study is to provide an effective basis for the prevention of non-hematological malignant tumors complicated with AKI in clinical work-Methods:From February 1,2018 to May 31,2019,4321 patients in the Konmyung Medical School 1st Hospital Oncology Department were examined for clinical data.Inclusion criteria:? meet the diagnostic criteria of AKI of the Kidney Disease Improing Global Outcomes(KDIGO);? patients with non-hematological malignant tumors was confirmed by Biopsy;The following are exclusion criteria:?patients under 18 years of age;? Patients requiring regular dialysis in the late stage of chronic kidney disease;? Patients with incomplete data.Then75 patients complicated with AKI and 2,890 non-AKI patients were selected to analyze the incidence of AKI,hospital mortality,related risk factors of AKI,prognostic factors of renal function,and prognostic factors of hospital survival of patients with non-hematological malignant tumors.Results:1.Of the 2965 patients with non-hematological malignant tumors,75 were complicated with AKI.The incidence of AKI in non-hematological malignant tumors was2.53%.Among the 75 patients,29 died during hospitalization,and the hospital mortality was 38.67%.Of the 2890 patients with non-hematological malignant tumors without AKI,543 died during hospitalization,and the hospital mortality was 18.79%.The hospital mortality of patients with AKI was significantly higher than that of patients without AKI.The difference was statistically significant(P<0.05).2.Univariate Logistic regression analysis showed that male patients were more likely to develop AKI than female patients.In addition,elderly patients,hyperuricemia,hypokalemia,hypocalcemia,hypoalbuminemia,anemia,sepsis,Hypertension is a high risk factor for AKI in patients with non-hematological malignant tumors(P<0.05);3.Multivariate Logistic regression analysis indicates hyperuricemia,sepsis,and hypocalcemia,and anemia are independent risk factors of patients with non-hematological malignant tumors complicated with AKI.(P<0.05).4.Univariate analysis of renal function in patients with non-hematological malignant tumors complicated with AKI in chi-square test showed that:oliguria,multiple organ failure,AKI stage,etiology of AKI and sepsis were the high risk factors affecting the prognosis of renal function.(P<0.05).5.Multivariate Logistic regression analysis showed that:AKI stage was an independent influencing factor for renal function prognosis of patients with non-hematological malignant tumors complicated with AKI(P<0.05).6.The univariate analysis of survival prognosis of patients with non-hematological malignant tumors complicated with AKI in chi-square test showed that oliguria,multiple organ failure,AKI stage and hypoalbuminemia were the high risk factors affecting the survival prognosis of patients with non-hematological malignant tumors complicated with AKI(P<0.05).7.Multivariate Logistic regression analysis showed that:multiple organ failure and AKI stage were independent influencing factors for patient survival prognosis of patients with non-hematological malignant tumors complicated with AKI(P<0.05).8.After follow-up,it was found that there were no significant differences in blood creatinine levels between 1 month,3 months,and 6 months after discharge from the patients(P>0.05).Conclusions:1.AKI is a frequent and serious complication in patients with non-hematological malignancies.Hyperuricemia,sepsis,hypocalcemia and anemia are independent risk factors of patients with non-hematological malignant tumors complicated with AKI.2.AKI staging is an independent factor affecting the prognosis of renal function in patients with non-hematological malignant tumors complicated with AKI.3.Multiple organ failure and AKI stage are independent influencing factors for patient survival prognosis in patients with non-hematological malignant tumors complicated with AKI,4.After follow-up,it was found that there were no significant differences in blood creatinine levels between 1 month,3 months,and 6 months after discharge from the patients(P>0.05).Therefore,during the hospitalization treatment of patients with non-blood system malignant tumors,medical staff should pay attention to the monitoring of AKI risk factors in order to take timely preventive measures and implement individualized treatment plans.When patients with non-hematological malignancies are complicated by AKI,the renal function of some patients can be restored and stabilized after timely treatment.