Analysis Of Risk Factors Associated With The Incidence Of Pediatric Malignant Solid Tumors In 140 Patients

Objective: Pediatric malignant solid tumors are the main cause of non-accidental death in children.Although existing treatment methods can cure some children's malignant tumors clinically,the date of radiotherapy and chemotherapy long-term effects on children's various organs and the lack of systematic follow-up data on recurrence and metastasis make studying risk factors associated with the development of malignant solid tumors in children important for reducing the incidence of malignenet tumors and improving the quality of the population.In this paper,we analyzed the risk factors related to the incidence of malignant solid tumors in children.By comparing factors such as maternal and infant characteristics between the case group and the control group,such as birth weight,maternal age,parental smoking,maternal education and family cancer history,Indicators that can predict independent risk factors.Methods: 140 children with malignant solid tumors and 142 non-tumor children of the same age group were selected and divided into case group and control group.Collecting and comparing the relevant factors of the two groups,including birth weight,maternal age,paternal age,abortion history,mode of delivery,assisted reproduction,birth order,parents smoking and drinking history,maternal education and family history of cancer.Odds ratios(OR)and 95 percent confidence intervals(CIs)were computed by unconditional logistic regression analysis.The difference was statistically significant according to the test level of which p<0.05.Results: Father drinking and family history of cancer were independent risk factors.Among children with solid tumors,the risk increased with fathers who drank alcohol(OR=6.48(95% CI,3.556-11.828).children with a family history of cancer had a higher probability of disease(OR=7.60(95% CI,2.950-19.583).The probability of tumor occurrence in the maternal age < 25 years old was(2.263(95% CI,1.098-4.664))times higher than that of the 25-35 years old group.Maternal ages larger than 35 years are not statistically significant compared with 25-35 years.Gender?birth weight?paternal age?abortion history?mode of delivery?assisted reproduction?birth order?paternal smoking?maternal smoking and drinking history?maternal education were not statistically significant.Conclusion: Father drinking and family history of cancer were independent risk factors,that is,the offspring born by fathers who have a history of drinking and family history of cancer are more likely to have solid tumors.The probability of tumor occurrence in the maternal age <25 years old was(2.263(95% CI,1.098-4.664))times higher than that of the 25-35 years old group.Maternal ages larger than 35 years are not statistically significant compared with 25-35 years.Pediatric solid tumors are concealed,lack of specific clinical manifestations and detection methods.During pregnancy,parents should avoid alcohol and tobacco as much as possible,and choose the best reproductive age.When there's a tumor in the family,we need to be alert and pay attention to children's physical abnormalities.take a doctor as early as possible.